Wong Rachel Shet Hui, Ashton Mark, Dodou Kalliopi
Department of Pharmacy Health and Wellbeing, Faculty of Applied Sciences, University of Sunderland, Science Complex, Wharncliffe Street, SR1 3SD Sunderland, UK.
Pharmaceutics. 2015 Sep 9;7(3):305-19. doi: 10.3390/pharmaceutics7030305.
Novel polyethylene oxide (PEO) hydrogel films were synthesized via UV crosslinking with varying concentrations of pentaerythritol tetra-acrylate (PETRA) as crosslinking agent. The aim was to study the effects of the crosslinking agent on the material properties of hydrogel films intended for dermatological applications. Fabricated film samples were characterized using swelling studies, scanning electron microscopy, tensile testing and rheometry. Films showed rapid swelling and high elasticity. The increase of PETRA concentration resulted in significant increase in the gel fraction and crosslinking density (ρc), while causing a significant decrease in the equilibrium water content (EWC), average molecular weight between crosslinks (({\overline{M}}_{c})), and mesh size (ζ) of films. From the scanning electron microscopy, cross-linked PEO hydrogel network appeared as cross-linked mesh-like structure with interconnected micropores. Rheological studies showed PEO films required a minimum of 2.5% w/w PETRA to form stable viscoelastic solid gels. Preliminary studies concluded that a minimum of 2.5% w/w PETRA is required to yield films with desirable properties for skin application.
通过紫外线交联，以不同浓度的季戊四醇四丙烯酸酯（PETRA）作为交联剂合成了新型聚环氧乙烷（PEO）水凝胶薄膜。目的是研究交联剂对用于皮肤科应用的水凝胶薄膜材料性能的影响。使用溶胀研究、扫描电子显微镜、拉伸测试和流变学对制备的薄膜样品进行表征。薄膜表现出快速溶胀和高弹性。PETRA浓度的增加导致凝胶分数和交联密度（ρc）显著增加，同时导致薄膜的平衡含水量（EWC）、交联点间平均分子量（({\overline{M}}_{c})）和网孔尺寸（ζ）显著降低。从扫描电子显微镜观察，交联的PEO水凝胶网络呈现为具有相互连接微孔的交联网状结构。流变学研究表明，PEO薄膜需要至少2.5% w/w的PETRA才能形成稳定的粘弹性固体凝胶。初步研究得出结论，需要至少2.5% w/w的PETRA才能得到具有适合皮肤应用性能的薄膜。
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