Maddi Abhiram, Alluri Leela Subhashini, Ciancio Sebastian G
J Int Acad Periodontol. 2015 Jul;17(3):77-81.
Drug-induced gingival overgrowth (DIGO) is an oral clinical manifestation associated with certain medications such as immunosuppressants that are administered to organ transplant patients to prevent graft rejection. In patients with cardiac transplants, management of DIGO is critical. In such patients, plaque biofilm accumulation at the gingival interface might be detrimental as it may lead to transient bacteremia as well as systemic inflammation resulting in thromboembolic events. This case report describes the management of DIGO in a cardiac transplant recipient by change of immunosuppressant medication, non-surgical periodontal therapy and laser-assisted gingivectomy.
药物性牙龈增生(DIGO)是一种口腔临床表现,与某些药物有关,如用于器官移植患者以预防移植排斥反应的免疫抑制剂。在心脏移植患者中,DIGO的管理至关重要。在此类患者中,牙龈界面处菌斑生物膜的积聚可能有害,因为它可能导致短暂性菌血症以及全身性炎症,进而引发血栓栓塞事件。本病例报告描述了通过改变免疫抑制药物、非手术牙周治疗和激光辅助牙龈切除术来管理一名心脏移植受者的DIGO。