[Neurologic and neuropsychologic manifestations in asymptomatic HIV positive subjects. Results of the first year follow-up].

Neurologic alterations were noted as important early from the description of the AIDS epidemic. At present, there is evidence that the Human Immunodeficiency Virus can be the aetiologic agent of the AIDS dementia complex. The natural history of this disease is not well known. Various longitudinal studies have been undertaken to assess the appearance of neurologic and neuropsychologic alterations in seropositive patients. Until now the results show that asymptomatic seropositive patients have not significant alterations. We are studying seropositive asymptomatic patients with haemophilia. The results of the first year of the study indicate that these patients, taken all together, have not significant alterations. However, neuropsychologic and subtle neurologic alterations were found in 3 patients (21%). If these findings are also observed in other similar studies, these group II "asymptomatic" patients will must be reclassified, with probable changes in management and prognosis.