Amer G, Arranz P, Bayes R, Magallón M, Pastor I, Urrutia G
Arch Neurobiol (Madr). 1989;52 Suppl 1:68-72.
Neurologic alterations were noted as important early from the description of the AIDS epidemic. At present, there is evidence that the Human Immunodeficiency Virus can be the aetiologic agent of the AIDS dementia complex. The natural history of this disease is not well known. Various longitudinal studies have been undertaken to assess the appearance of neurologic and neuropsychologic alterations in seropositive patients. Until now the results show that asymptomatic seropositive patients have not significant alterations. We are studying seropositive asymptomatic patients with haemophilia. The results of the first year of the study indicate that these patients, taken all together, have not significant alterations. However, neuropsychologic and subtle neurologic alterations were found in 3 patients (21%). If these findings are also observed in other similar studies, these group II "asymptomatic" patients will must be reclassified, with probable changes in management and prognosis.
从艾滋病流行的描述开始，神经系统改变就被视为重要的早期症状。目前，有证据表明人类免疫缺陷病毒可能是艾滋病痴呆综合征的病原体。这种疾病的自然史尚不清楚。已经进行了各种纵向研究来评估血清反应阳性患者神经和神经心理改变的出现情况。到目前为止，结果表明无症状血清反应阳性患者没有明显改变。我们正在研究患血友病的无症状血清反应阳性患者。该研究第一年的结果表明，总体而言，这些患者没有明显改变。然而，在3名患者（21%）中发现了神经心理和细微的神经系统改变。如果在其他类似研究中也观察到这些发现，那么这些II组“无症状”患者将必须重新分类，这可能会改变治疗和预后。
