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一些作为潜在杀菌剂的吡唑啉和异恶唑啉衍生物的合成

Synthesis of some pyrazoline and isoxazolin derivatives as possible fungicides.

作者信息

Tiwari N, Dwivedi B

出版信息

Boll Chim Farm. 1989 Nov;128(11):332-5.

PMID:2637751
Abstract

1-Acetyl/aroyl-3-methyl-4-substituted anilido-5-aryl pyrazolines and 3-methyl-4-substituted anilido-5-aryl isoxazolines were conveniently prepared from synthon, 4-aryl-3-substituted anilido but-3-en-2-ones in presence of hydrazine hydrate/hydrazides and hydroxylamine hydrochloride respectively. All the compounds have been assayed against Cephalosporium sacchari and Helminthosporium oryzae and found remarkably active. Two species of aquatic fungi viz. Saprolegnia parasitica and Achlya orion responsible for fish mycoses were tested and also found remarkably active.

摘要

1-乙酰基/芳酰基-3-甲基-4-取代苯胺基-5-芳基吡唑啉和3-甲基-4-取代苯胺基-5-芳基异恶唑啉分别由合成子4-芳基-3-取代苯胺基丁-3-烯-2-酮在水合肼/酰肼和盐酸羟胺存在下方便地制备而成。所有化合物均已针对甘蔗头孢霉和稻瘟病菌进行了测定,发现具有显著活性。对两种引起鱼类霉菌病的水生真菌,即寄生水霉和猎户座绵霉进行了测试,也发现具有显著活性。

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