一些吡唑啉衍生物的制备及其抗真菌活性评价。
Preparation of some pyrazoline derivatives and evaluation of their antifungal activities.
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
出版信息
J Enzyme Inhib Med Chem. 2010 Aug;25(4):565-71. doi: 10.3109/14756360903373368.
The synthesis of a new series of 1-[(benzazole-2-yl)thioacetyl]-3,5-diaryl-2-pyrazoline derivatives was obtained by reacting 1-(chloroacetyl)-3,5-diaryl-pyrazolines with 2-mercaptobenzimidazole/benzoxazole/benzothiazole. The chemical structures of the compounds were elucidated by (1)H-NMR, (13)C-NMR, and FAB(+)-MS spectral data. Their antifungal activities against Candida albicans, Candida glabrata, Candida utilis, Candida tropicalis, Candida krusei, and Candida parapsilosis were investigated. A significant level of activity was observed.
通过将 1-(氯乙酰基)-3,5-二芳基吡唑啉与 2-巯基苯并咪唑/苯并恶唑/苯并噻唑反应，得到了一系列新的 1-[(苯并唑-2-基)硫代乙酰基]-3,5-二芳基-2-吡唑啉衍生物的合成。通过（1）H-NMR、（13）C-NMR 和 FAB(+)-MS 光谱数据阐明了化合物的化学结构。研究了它们对白色念珠菌、光滑念珠菌、产朊假丝酵母、热带假丝酵母、克柔假丝酵母和近平滑假丝酵母的抗真菌活性。观察到显著的活性水平。
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