抑制蛋白的发育：β-抑制蛋白在发育信号通路中的新作用
Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways.
作者信息
Kovacs Jeffrey J, Hara Makoto R, Davenport Chandra L, Kim Jihee, Lefkowitz Robert J
机构信息
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
出版信息
Dev Cell. 2009 Oct;17(4):443-58. doi: 10.1016/j.devcel.2009.09.011.
Abstract
Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and downstream kinases such as the MAPK and Akt/PI3K cascades. The involvement of arrestins in many discrete developmental signaling events suggests an indispensable role for these multifaceted molecular scaffolds.
摘要
抑制蛋白被鉴定为G蛋白偶联受体（GPCR）脱敏和内吞作用的介质。然而，现在很清楚的是，它们构建了许多细胞内信号网络，以调节多种类型受体（包括与刺猬信号通路、Wnt信号通路、Notch信号通路和转化生长因子β信号通路相关的受体）以及下游激酶（如丝裂原活化蛋白激酶和Akt/磷脂酰肌醇-3激酶级联反应）的信号强度和持续时间。抑制蛋白参与许多离散的发育信号事件，表明这些多面分子支架具有不可或缺的作用。
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