Mo Yanli, Peng Jiayin, Su Wenmei, Chen Xinggui, Wu Aibing, Li Jinmei, Yang Zhixiong
Department of Oncology, Affiliated Hospital of Guangdong Medical University 57 Renmin Road, Zhanjiang, PR China.
Department of Urology, Zhanjiang Central People's Hospital 2 Cunjin Road, Zhanjiang, PR China.
Int J Clin Exp Med. 2015 Jul 15;8(7):11675-82. eCollection 2015.
According to the newest version of NCCN Clinical Practice Guidelines for Non-Small Cell Lung Cancer (NSCLC), increasing attentions are paid to the role of nodal status and other high-risk factors, including vascular invasion, wedge resection, tumors > 4 cm, visceral pleural involvement, and incomplete lymph node sampling in the individual clinical treatment. Precise definitions of T status and N status, closely associated with prognosis and treatment, are worth expanding further. However, complexity arises because no unity definition exists regarding individual T and N descriptors. In an attempt to explore the potential prognostic values of the T status and N status, we systematically review relevant literature and found that there still remained some disputes about the definitions and prognosis. The adjacent lobe invasion regarded as T2 or T3 has not been reached consensus yet so far. Lymph node spread patterns are associated with the treatment strategies of NSCLC. This review mainly focus on the role of T status and N status and tried to seek appropriate and individual treatment strategies in NSCLC.
根据最新版美国国立综合癌症网络（NCCN）非小细胞肺癌（NSCLC）临床实践指南，人们越来越关注淋巴结状态及其他高危因素在个体临床治疗中的作用，这些因素包括血管侵犯、楔形切除、肿瘤直径>4 cm、脏层胸膜受累以及淋巴结采样不完整。与预后和治疗密切相关的T分期和N分期的精确界定值得进一步拓展。然而，由于对于个体T和N描述符不存在统一的定义，这就产生了复杂性。为了探索T分期和N分期的潜在预后价值，我们系统回顾了相关文献，发现关于其定义和预后仍存在一些争议。目前，对于被视为T2或T3的邻近肺叶侵犯尚未达成共识。淋巴结转移模式与NSCLC的治疗策略相关。本综述主要关注T分期和N分期的作用，并试图探寻NSCLC合适的个体化治疗策略。
