Bachtiar Velicia, Near Jamie, Johansen-Berg Heidi, Stagg Charlotte J
Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.
Elife. 2015 Sep 18;4:e08789. doi: 10.7554/eLife.08789.
We previously demonstrated that network level functional connectivity in the human brain could be related to levels of inhibition in a major network node at baseline (Stagg et al., 2014). In this study, we build upon this finding to directly investigate the effects of perturbing M1 GABA and resting state functional connectivity using transcranial direct current stimulation (tDCS), a neuromodulatory approach that has previously been demonstrated to modulate both metrics. FMRI data and GABA levels, as assessed by Magnetic Resonance Spectroscopy, were measured before and after 20 min of 1 mA anodal or sham tDCS. In line with previous studies, baseline GABA levels were negatively correlated with the strength of functional connectivity within the resting motor network. However, although we confirm the previously reported findings that anodal tDCS reduces GABA concentration and increases functional connectivity in the stimulated motor cortex; these changes are not correlated, suggesting they may be driven by distinct underlying mechanisms.
我们之前证明，人类大脑中的网络水平功能连接可能与基线时一个主要网络节点的抑制水平相关（Stagg等人，2014年）。在本研究中，我们基于这一发现，使用经颅直流电刺激（tDCS）直接研究干扰M1区γ-氨基丁酸（GABA）和静息态功能连接的影响，tDCS是一种神经调节方法，此前已证明它能调节这两个指标。在1毫安的阳极或假tDCS刺激20分钟前后，通过磁共振波谱评估的功能磁共振成像（fMRI）数据和GABA水平被测量。与之前的研究一致，基线GABA水平与静息运动网络内功能连接的强度呈负相关。然而，尽管我们证实了之前报道的结果，即阳极tDCS会降低GABA浓度并增加受刺激运动皮层的功能连接；但这些变化并无相关性，这表明它们可能由不同的潜在机制驱动。
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