Stagg Charlotte J, Bachtiar Velicia, Amadi Ugwechi, Gudberg Christel A, Ilie Andrei S, Sampaio-Baptista Cassandra, O'Shea Jacinta, Woolrich Mark, Smith Stephen M, Filippini Nicola, Near Jamie, Johansen-Berg Heidi
Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Elife. 2014 Mar 25;3:e01465. doi: 10.7554/eLife.01465.
Anatomically plausible networks of functionally inter-connected regions have been reliably demonstrated at rest, although the neurochemical basis of these 'resting state networks' is not well understood. In this study, we combined magnetic resonance spectroscopy (MRS) and resting state fMRI and demonstrated an inverse relationship between levels of the inhibitory neurotransmitter GABA within the primary motor cortex (M1) and the strength of functional connectivity across the resting motor network. This relationship was both neurochemically and anatomically specific. We then went on to show that anodal transcranial direct current stimulation (tDCS), an intervention previously shown to decrease GABA levels within M1, increased resting motor network connectivity. We therefore suggest that network-level functional connectivity within the motor system is related to the degree of inhibition in M1, a major node within the motor network, a finding in line with converging evidence from both simulation and empirical studies. DOI: http://dx.doi.org/10.7554/eLife.01465.001.
在静息状态下，功能相互连接区域的解剖学上合理的网络已得到可靠证实，尽管这些“静息状态网络”的神经化学基础尚未得到很好的理解。在本研究中，我们结合了磁共振波谱（MRS）和静息态功能磁共振成像（fMRI），并证明了初级运动皮层（M1）内抑制性神经递质GABA的水平与静息运动网络的功能连接强度之间存在反比关系。这种关系在神经化学和解剖学上都是特异性的。然后我们继续表明，阳极经颅直流电刺激（tDCS），一种先前已被证明可降低M1内GABA水平的干预措施，增加了静息运动网络的连接性。因此，我们认为运动系统内的网络水平功能连接与运动网络中的主要节点M1的抑制程度有关，这一发现与模拟和实证研究的一致证据相符。DOI: http://dx.doi.org/10.7554/eLife.01465.001 。
