Mali Gaurao Vasant, Dodamani Arun Suresh, Karibasappa Gundabaktha Nagappa, Kumar Prashanth Vishwakarma, Jain Vardhaman Mulchand
Department of Public Health Dentistry, ACPM Dental College, Dhule, Maharashtra, India.
J Indian Soc Pedod Prev Dent. 2015 Oct-Dec;33(4):331-6. doi: 10.4103/0970-4388.165707.
To assess and compare the effect of conventional and sugar free pediatric syrup formulations on primary tooth enamel hardness over a period of 14 days.
An in vitro study was done on 40 noncarious deciduous teeth. 10 teeth in each group were dipped in 4 pediatric medicinal syrups (1 sugarfree and 3 conventional) for 1 min thrice daily for 14 days and the enamel surface micro hardness was checked at baseline, 7 th day and 14 th day by Vickers hardness testing machine. The pH, titratable acidity and buffering capacity of the syrups were assessed.
The pH of syrups were above critical pH for demineralization of the tooth but tiratable acidity and buffering capacity differed. ANOVA test indicated that the reduction in mean micro hardness was maximum in Group D (Conventional Analgesic syrup) and least in Group A (Sugarfree cough syrup) on 7 th and 14 th day. On intergroup comparison there was no difference (P > 0.05) in micro hardness between Group B (Conventional Cough syrup) and Group C (Conventional Antibiotic). However, highly significant (P < 0.01) difference between the either pair of Group B with Group D, and Group C with Group D on 14 th day. The percentage reduction in micro hardness on 14 th day was maximum for Group D (24.4 ± 2.2) and minimum for Group A (14.0 ± 1.3) which was statistically significant (P < 0.01).
Sugar free pediatric medicines can be effective in reducing dental erosion and efforts should be made to incorporate sugar substitutes in formulation of pediatric medicines.
评估并比较传统配方和无糖儿科糖浆制剂在14天内对乳牙牙釉质硬度的影响。
对40颗非龋乳牙进行体外研究。每组10颗牙齿每天3次浸入4种儿科药用糖浆（1种无糖和3种传统配方）中1分钟，持续14天，并在基线、第7天和第14天通过维氏硬度测试机检查牙釉质表面显微硬度。评估糖浆的pH值、可滴定酸度和缓冲能力。
糖浆的pH值高于牙齿脱矿的临界pH值，但可滴定酸度和缓冲能力有所不同。方差分析表明，在第7天和第14天，D组（传统镇痛糖浆）的平均显微硬度降低最大，A组（无糖止咳糖浆）最小。组间比较显示，B组（传统止咳糖浆）和C组（传统抗生素糖浆）之间的显微硬度无差异（P>0.05）。然而，在第14天，B组与D组、C组与D组之间的差异高度显著（P<0.01）。第14天显微硬度降低百分比最大的是D组（24.4±2.2），最小的是A组（14.0±1.3），具有统计学意义（P<0.01）。
无糖儿科药物可有效减少牙齿侵蚀，应努力在儿科药物配方中加入糖替代品。
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