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头皮银屑病的当前管理

Current management of scalp psoriasis.

作者信息

Guenther L

机构信息

Division of Dermatology, University of Western Ontario, London, ON, Canada; The Guenther Dermatology Research Centre (GDRC), London, ON, Canada.

出版信息

Skin Therapy Lett. 2015 May-Jun;20(3):5-7.

Abstract

The scalp is involved in up to 80% of individuals with psoriasis. Eighty percent of those with scalp psoriasis experience a negative impact on quality of life. Topical treatment with corticosteroids with or without vitamin D3 analogues is the mainstay of treatment. Topical therapy most suitable for the scalp is formulated as a solution, lotion, gel, foam, spray, oil, or shampoo. Twice weekly maintenance in frequent relapsers may decrease the time to first relapse. Intralesional steroids, phototherapy and the excimer laser are occasionally used for resistant cases. In patients with moderate-to-severe psoriasis, apremilast, adalimumab and etanercept have been shown to significantly improve scalp psoriasis. They should be considered in patients who have failed topical therapy.

摘要

高达80%的银屑病患者头皮会受累。80%的头皮银屑病患者的生活质量受到负面影响。使用或不使用维生素D3类似物的皮质类固醇局部治疗是主要的治疗方法。最适合头皮的局部治疗制剂有溶液、洗剂、凝胶、泡沫、喷雾剂、油剂或洗发水。对于频繁复发者,每周两次的维持治疗可能会延长首次复发的时间。皮损内注射类固醇、光疗和准分子激光偶尔用于治疗耐药病例。在中重度银屑病患者中,阿普斯特、阿达木单抗和依那西普已被证明能显著改善头皮银屑病。对于局部治疗失败的患者应考虑使用这些药物。

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