Papp K, Berth-Jones J, Kragballe K, Wozel G, de la Brassinne M
Probity Medical Research-Union, Waterloo, Ontario, Canada.
J Eur Acad Dermatol Venereol. 2007 Oct;21(9):1151-60. doi: 10.1111/j.1468-3083.2007.02424.x.
The scalp is the most common site of disease involvement at the onset and throughout the course of psoriasis. For many patients, psoriasis of the scalp is the most difficult aspect of their disease; yet, despite a wide range of therapy options and an extensive literature base, scalp psoriasis remains difficult to treat, highlighting a long-standing unmet need for the effective treatment of scalp psoriasis. A review of past and current medical literature reveals that a number of interesting therapeutic approaches have been used in the treatment of scalp psoriasis. The diverse and sometimes extreme therapeutic approaches, the marginal benefit of many topical agents, the paucity of controlled studies evaluating the efficacy of topical agents in the treatment of scalp psoriasis and the high level of patient dissatisfaction with currently available treatments for psoriasis all support the need for new, effective and well-tolerated treatment options for scalp psoriasis.
头皮是银屑病发病初期及整个病程中最常受累的部位。对许多患者而言，头皮银屑病是其病情中最棘手的方面；然而，尽管有广泛的治疗选择和丰富的文献基础，头皮银屑病仍然难以治疗，这凸显了长期以来对有效治疗头皮银屑病的未满足需求。回顾过去和当前的医学文献发现，在头皮银屑病的治疗中使用了许多有趣的治疗方法。多样且有时极端的治疗方法、许多外用药物的边际效益、评估外用药物治疗头皮银屑病疗效的对照研究匮乏以及患者对目前可用的银屑病治疗方法的高度不满，都表明需要新的、有效且耐受性良好的头皮银屑病治疗选择。
