Coscas G, Soubrane G, Sterkers M, Glacet-Bernard A
Clinique Ophthalmologique universitaire de Créteil, Université Paris-XII.
J Fr Ophtalmol. 1989;12(10):613-21.
The tunable dye laser provides now a large assortment of monochromatic wavelengths that allow selective targeting on individual tissues in the retina, according to in vitro studies showing extinction coefficient of ocular pigments (xanthophyllic pigment, rhodopsin, melanin, lipofuschin, hemoglobin) for different laser wavelengths. Confluent heavy and juxtafoveolar laser burns in eyes of cynomolgus monkeys showed, after 38 days, similar lesions in all the wavelength studied (green, red, yellow, orange) at the level of the choriocapillaris, Bruch's membrane, pigment epithelium and photoreceptor's layers. However, the inner retina layers were discretely more damaged with yellow and orange than with green and red. In clinical approach, the effects of these different wavelength haven been compared in human eyes presenting with subfoveol new vessels and disciform age-related macular degeneration. After healing, the scar was similar biomicroscopically, and on fluorescein angiography with all wavelengths studied (green, red, yellow, orange). In conclusion, dye laser seems to be efficient and easily tunable for photocoagulation in macular area.
根据体外研究显示不同激光波长下眼部色素（叶黄素色素、视紫红质、黑色素、脂褐素、血红蛋白）的消光系数，可调谐染料激光器现在提供了大量单色波长，可对视网膜中的单个组织进行选择性靶向。在食蟹猴眼中进行的融合性重度和黄斑旁激光烧伤，38天后，在脉络膜毛细血管、布鲁赫膜、色素上皮和光感受器层水平上，所有研究波长（绿色、红色、黄色、橙色）均显示出类似病变。然而，与绿色和红色相比，黄色和橙色对视网膜内层的损伤更为明显。在临床实践中，对患有黄斑下新生血管和盘状年龄相关性黄斑变性的人眼比较了这些不同波长的效果。愈合后，在生物显微镜下以及在所有研究波长（绿色、红色、黄色、橙色）的荧光素血管造影中，瘢痕相似。总之，染料激光似乎对黄斑区光凝有效且易于调谐。
