Wang Hua, Maitra Anirban, Wang Huamin
Department of Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, United States.
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, United States; Department of Translational Molecular Pathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 77030, United States.
Semin Cancer Biol. 2016 Feb;36:88-94. doi: 10.1016/j.semcancer.2015.09.004. Epub 2015 Sep 16.
The role of F-box proteins in pancreatic tumorigenesis is emerging owing to their pivotal and indispensable roles in cell differentiation, cell cycle regulation and proliferation. In this review, we will focus on β-TrCP (β-transducin repeat-containing protein) and two other prototypical mammalian F-box proteins, Fbxw7 and Fbxw8, in pancreatic tumorigenesis and progression. We will highlight the functions and regulation of these F-box proteins, their respective substrates and cross-talks with other key signaling pathways, such as the Ras-Raf-Mek-Erk, Hedgehog, NFκB, TGF-β, Myc and HPK1 signaling pathways in pancreatic cancer.
由于F-box蛋白在细胞分化、细胞周期调控和增殖中起着关键且不可或缺的作用，其在胰腺肿瘤发生中的作用正逐渐显现。在本综述中，我们将聚焦于β-TrCP（含β-转导蛋白重复序列的蛋白）以及另外两种典型的哺乳动物F-box蛋白Fbxw7和Fbxw8在胰腺肿瘤发生和进展中的作用。我们将重点介绍这些F-box蛋白的功能和调控、它们各自的底物以及与其他关键信号通路（如胰腺癌中的Ras-Raf-Mek-Erk、Hedgehog、NFκB、TGF-β、Myc和HPK1信号通路）的相互作用。
