系统评价与荟萃分析：镰状细胞病患儿的药物依从性
Systematic and Meta-Analytic Review: Medication Adherence Among Pediatric Patients With Sickle Cell Disease.
作者信息
Loiselle Kristin, Lee Jennifer L, Szulczewski Lauren, Drake Sarah, Crosby Lori E, Pai Ahna L H
机构信息
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center.
出版信息
J Pediatr Psychol. 2016 May;41(4):406-18. doi: 10.1093/jpepsy/jsv084. Epub 2015 Sep 18.
OBJECTIVE
To provide a comprehensive summary (systematic review) of medication adherence rates by assessment method and medication type for pediatric patients with sickle cell disease (SCD), as well as identify important correlates for future research.
METHODS
Articles assessing medication adherence and published between 1982 and February 2015 (n = 49) were identified using electronic databases. A meta-analysis of 14 studies examining demographic, medical, and psychosocial factors and medication adherence was conducted.
RESULTS
Adherence rates ranged from 12% to 100% across all medications. Approximately 30% of studies reported associations between adherence and key demographic, medical, and psychosocial correlates. Mean effect sizes were small to moderate (r = .02-.53).
CONCLUSIONS
The wide range of adherence rates reported in the literature may be because of, in part, the use of variable assessment strategies. Future studies examining pediatric SCD adherence should incorporate key correlates with the goal of replication.
目的
通过评估方法和药物类型，全面总结镰状细胞病（SCD）儿科患者的用药依从率，并确定未来研究的重要相关因素。
方法
利用电子数据库检索1982年至2015年2月间发表的评估用药依从性的文章（n = 49）。对14项研究进行荟萃分析，这些研究考察了人口统计学、医学和社会心理因素与用药依从性之间的关系。
结果
所有药物的依从率在12%至100%之间。约30%的研究报告了依从性与关键人口统计学、医学和社会心理相关因素之间的关联。平均效应大小为小到中等（r = 0.02 - 0.53）。
结论
文献中报道的依从率范围广泛，部分原因可能是评估策略的多样性。未来研究儿科SCD患者的依从性时，应纳入关键相关因素以实现重复研究的目标。
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