Kim Dae-Jin, Davis Elysia Poggi, Sandman Curt A, Sporns Olaf, O'Donnell Brian F, Buss Claudia, Hetrick William P
Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th Street, Bloomington, IN 47405, USA.
Department of Psychology, University of Denver, 2155 South Race Street, Denver, CO 80208, USA; Department of Psychiatry and Human Behavior, University of California Irvine, One University Drive, Orange, CA 92866, USA.
Neuroimage. 2016 Jan 1;124(Pt A):550-556. doi: 10.1016/j.neuroimage.2015.09.012. Epub 2015 Sep 15.
Recent structural and functional neuroimaging studies of adults suggest that efficient patterns of brain connectivity are fundamental to human intelligence. Specifically, whole brain networks with an efficient small-world organization, along with specific brain regions (i.e., Parieto-Frontal Integration Theory, P-FIT) appear related to intellectual ability. However, these relationships have not been studied in children using structural network measures. This cross-sectional study examined the relation between non-verbal intellectual ability and structural network organization in 99 typically developing healthy preadolescent children. We showed a strong positive association between the network's global efficiency and intelligence, in which a subtest for visuo-spatial motor processing (Block Design, BD) was prominent in both global brain structure and local regions included within P-FIT as well as temporal regions involved with pattern and form processing. BD was also associated with rich club organization, which encompassed frontal, occipital, temporal, hippocampal, and neostriatal regions. This suggests that children's visual construction ability is significantly related to how efficiently children's brains are globally and locally integrated. Our findings indicate that visual construction and reasoning may make general demands on globally integrated processing by the brain.
近期针对成年人的结构与功能神经影像学研究表明，高效的脑连接模式是人类智力的基础。具体而言，具有高效小世界组织特性的全脑网络，以及特定脑区（即顶叶 - 额叶整合理论，P - FIT）似乎与智力能力相关。然而，尚未使用结构网络测量方法在儿童中对这些关系进行研究。这项横断面研究调查了99名发育正常的健康青春期前儿童的非言语智力能力与结构网络组织之间的关系。我们发现网络的全局效率与智力之间存在强烈的正相关，其中视觉空间运动处理子测试（积木图案，BD）在全脑结构以及P - FIT所包含的局部区域以及与图案和形状处理相关的颞叶区域中都很突出。BD还与丰富俱乐部组织相关，该组织涵盖额叶、枕叶、颞叶、海马体和新纹状体区域。这表明儿童的视觉构建能力与儿童大脑在全局和局部的整合效率显著相关。我们的研究结果表明，视觉构建和推理可能对大脑的全局整合处理提出了一般性要求。
