肠胃外使用苯甲酸钠咖啡因：中国丙型肝炎病毒传播中一个被低估的风险因素。
Use of parenteral caffeinum natrio-benzoicum: an underestimated risk factor for HCV transmission in China.
作者信息
Xu Hongqin, Yu Ge, Sun Haibo, Lv Juan, Wang Moli, Kong Fei, Zhang Mingyuan, Chi Xiumei, Wang Xiaomei, Wu Ruihong, Gao Xiuzhu, Zhong Jin, Sun Bing, Jiang Jing, Pan Yu, Niu Junqi
机构信息
Department of Hepatology, The First Hospital of Jilin University, No.71 Xinmin Street, Changchun, 130021, China.
Ministry of Education; Key Laboratory of Zoonosis, No.519 Dongminzhu Street, Changchun, 130061, China.
出版信息
BMC Public Health. 2015 Sep 19;15:928. doi: 10.1186/s12889-015-2299-8.
BACKGROUND
Fuyu city in China has a high prevalence of hepatitis C virus (HCV) infection resulting in a high morbidity and mortality from chronic liver disease and hepatocellular carcinoma. This study was conducted to identify the risk factors for HCV infection in Fuyu city.
METHODS
Recruitment of study subjects involved a cross-sectional survey using non-random, convenience sampling. Information on demographic variables, risk factors for HCV infection, clinical manifestations, behavioral practices and family history was collected by administering a questionnaire. Anti-HCV antibody was detected using Abbott ARCHITECT i2000SR. HCV infection was confirmed by HCV-RNA testing by the Roche Taqman HCV test. Univariate and multivariate analyses were performed to identify the factors associated with HCV infection.
RESULTS
Out of 3,228 persons that participated in the survey, 3,219 were enrolled in the study. The prevalence of HCV infection was 42.1 % (1355/3219). Among 734 patients with chronic HCV infection whose HCV-RNA genotyping was performed, genotype 1b was the most common (58.0 %), followed by genotype 2a (40.2 %), while co-infection with genotypes 1b and 2a was detected in 1.8 % of the subjects. On univariate analysis, male gender, older age, parenteral caffeinum natrio-benzoicum and share syringes (PCNBSS), and nine other factors were significantly associated with HCV infection. After adjusting for potential confounders, male gender, old age, cigarette smoking, lower education level, history of blood transfusion, blood donation, prior dental surgery, and PCNBSS were found to be independently associated with HCV infection.
CONCLUSIONS
The prevalence of HCV infection is likely to be high among residents in Fuyu and we observed that genotypes 1b and 2a dominated in the city. Our findings support the hypothesis that PCNBSS which became endemic in Fuyu city during 1970s-1980s is strongly associated with HCV positivity.
背景
中国扶余市丙型肝炎病毒（HCV）感染率很高，导致慢性肝病和肝细胞癌的发病率和死亡率居高不下。本研究旨在确定扶余市HCV感染的危险因素。
方法
研究对象的招募采用非随机便利抽样的横断面调查。通过问卷调查收集人口统计学变量、HCV感染危险因素、临床表现、行为习惯和家族史等信息。采用雅培ARCHITECT i2000SR检测抗HCV抗体。通过罗氏Taqman HCV检测进行HCV-RNA检测以确诊HCV感染。进行单因素和多因素分析以确定与HCV感染相关的因素。
结果
在参与调查的3228人中，3219人纳入研究。HCV感染率为42.1%（1355/3219）。在734例进行HCV-RNA基因分型的慢性HCV感染患者中，1b型最为常见（58.0%），其次是2a型（40.2%），1.8%的受试者检测到1b型和2a型合并感染。单因素分析显示，男性、年龄较大、静脉注射苯甲酸钠咖啡因和共用注射器（PCNBSS）以及其他九个因素与HCV感染显著相关。在对潜在混杂因素进行校正后，发现男性、年龄较大、吸烟、教育程度较低、输血史、献血史、既往牙科手术史和PCNBSS与HCV感染独立相关。
结论
扶余市居民中HCV感染率可能很高，我们观察到1b型和2a型在该市占主导地位。我们的研究结果支持以下假设，即20世纪70年代至80年代在扶余市流行的PCNBSS与HCV阳性密切相关。
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