Hunan Provincial Center for Diseases Control and Prevention, 450 Furongzhong Rd. sec 1, Changsha 410005, China.
Arch Virol. 2013 Sep;158(9):1889-94. doi: 10.1007/s00705-013-1681-z. Epub 2013 Apr 4.
Co-infection of hepatitis B virus (HBV) and/or hepatitis C virus (HCV) with human immunodeficiency virus (HIV) has an adverse effect on liver disease progression. This study investigated the prevalence of HBV and/or HCV co-infection in HIV-infected patients in Central China. A total of 978 HIV-infected patients from Hunan Province were enrolled. HBV serum markers, anti-hepatitis-C-virus antibody (anti-HCV), HBV DNA, and HBV genotypes were analyzed. The prevalence of hepatitis B surface antigen (HBsAg) and anti-HCV in HIV-infected patients was 19.4 % and 62.4 %, respectively. The prevalence of anti-HCV in HIV-positive intravenous drug users was 93.6 %. Among HBsAg-positive patients, 88.1 % were found to have at least one HBV serum marker. The rates of HIV mono-infection, HBV/HIV dual infection, HCV/HIV dual infection, and HBV/HCV/HIV triple infection were 30.4 %, 7.2 %, 50.2 %, and 12.2 %, respectively. Antibody to HBsAg (Anti-HBs) was more common in anti-HCV-positive than anti-HCV-negative patients (53.3 % vs 40.2 %, P = 0.000), but isolated hepatitis B core antibody (anti-HBc) was more common in anti-HCV-negative than anti-HCV-positive patients (24.2 % vs 12.3 %, P = 0.000). Hepatitis B e antigen (HBeAg) and sexual transmission were independent risk factors for active HBV replication. Intravenous drug use and male sex were independent risk factors, but old age and presence of HBeAg were independent protective factors for anti-HCV. Co-infection of HBV and/or HCV with HIV infection is common in central China. HCV status is associated with anti-HBs and isolated anti-HBc in co-infected patients.
乙型肝炎病毒 (HBV) 和/或丙型肝炎病毒 (HCV) 与人类免疫缺陷病毒 (HIV) 的合并感染对肝病进展有不良影响。本研究调查了中国中部地区 HIV 感染者中 HBV 和/或 HCV 合并感染的流行情况。共纳入湖南省 978 例 HIV 感染者。分析了 HBV 血清标志物、抗丙型肝炎病毒抗体 (抗-HCV)、HBV DNA 和 HBV 基因型。HIV 感染者 HBsAg 和抗-HCV 的阳性率分别为 19.4%和 62.4%。HIV 阳性静脉吸毒者的抗-HCV 阳性率为 93.6%。HBsAg 阳性患者中，88.1%至少有一种 HBV 血清标志物。HIV 单一感染、HBV/HIV 双重感染、HCV/HIV 双重感染和 HBV/HCV/HIV 三重感染的发生率分别为 30.4%、7.2%、50.2%和 12.2%。抗-HCV 阳性患者的抗-HBs 更为常见（53.3%比 40.2%，P=0.000），而抗-HCV 阴性患者的单纯乙型肝炎核心抗体（抗-HBc）更为常见（24.2%比 12.3%，P=0.000）。HBeAg 和性传播是 HBV 复制活跃的独立危险因素。静脉吸毒和男性是 HCV 感染的独立危险因素，但年龄较大和 HBeAg 阳性是 HCV 感染的独立保护因素。HBV 和/或 HCV 与 HIV 感染的合并感染在中国中部地区很常见。HCV 状态与合并感染患者的抗-HBs 和单纯抗-HBc 相关。
