量化健康人和哮喘患者最大呼气流量-容积曲线的形状。
Quantifying the shape of maximal expiratory flow-volume curves in healthy humans and asthmatic patients.
作者信息
Dominelli Paolo B, Molgat-Seon Yannick, Foster Glen E, Dominelli Giulio S, Haverkamp Hans C, Henderson William R, Sheel A William
机构信息
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.
出版信息
Respir Physiol Neurobiol. 2016 Jan;220:46-53. doi: 10.1016/j.resp.2015.09.007. Epub 2015 Sep 18.
Differences in the absolute flow and volume of maximal expiratory flow-volume (MEFV) curves have been studied extensively in health and disease. However, the shapes of MEFV curves have received less attention. We questioned if the MEFV curve shape was associated with (i) expiratory flow limitation (EFL) in health and (ii) changes in bronchial caliber in asthmatics. Using the slope-ratio (SR) index, we quantified MEFV curve shape in 84 healthy subjects and 8 matched asthmatics. Healthy subjects performed a maximal exercise test to assess EFL. Those with EFL during had a greater SR (1.15 ± 0.20 vs. 0.85 ± 0.20, p<0.05) yet, there was no association between maximal oxygen consumption and SR (r=0.14, p>0.05). Asthmatics average SR was greater than the healthy subjects (1.35 ± 0.03 vs. 0.90 ± 0.11, p<0.05), but there were no differences when bronchial caliber was manipulated. In conclusion, a greater SR is related to EFL and this metric could aid in discriminating between groups known to differ in the absolute size of MEFV curves.
最大呼气流量-容积（MEFV）曲线的绝对流量和容积差异在健康和疾病状态下已得到广泛研究。然而，MEFV曲线的形状却较少受到关注。我们探讨了MEFV曲线形状是否与以下因素相关：（i）健康状态下的呼气流量受限（EFL）；（ii）哮喘患者支气管管径的变化。我们使用斜率比（SR）指数对84名健康受试者和8名匹配的哮喘患者的MEFV曲线形状进行了量化。健康受试者进行了最大运动试验以评估EFL。存在EFL的受试者SR更高（1.15±0.20 vs. 0.85±0.20，p<0.05），然而，最大耗氧量与SR之间并无关联（r=0.14，p>0.05）。哮喘患者的平均SR大于健康受试者（1.35±0.03 vs. 0.90±0.11，p<0.05），但在支气管管径受到控制时并无差异。总之，更高的SR与EFL相关，并且该指标有助于区分已知MEFV曲线绝对大小存在差异的不同组。
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