Viganò F, Dimou L
Physiological Genomics, Biomedical Center, Ludwig-Maximilians University, Munich 80336, Germany.
Physiological Genomics, Biomedical Center, Ludwig-Maximilians University, Munich 80336, Germany; Institute for Stem Cell Research, Helmholtz Zentrum Munich, Neuherberg 85764, Germany; SYNERGY, Excellence Cluster of Systemic Neurology, Ludwig-Maximilians-University, Munich 81377, Germany.
Brain Res. 2016 May 1;1638(Pt B):129-137. doi: 10.1016/j.brainres.2015.09.012. Epub 2015 Sep 24.
In the central nervous system, NG2-glia are the cells responsible for the generation of mature oligodendrocytes during development and adulthood. Some studies could show that NG2-glia can give origin also to astrocytes and neurons, a property that makes them similar to neural stem cells. Beside their important role as progenitors, NG2-glia are believed also to have more functions due to their unique interaction with neurons through synapses. It is however not clear whether these features are common to all NG2-glia or different subpopulations of NG2-glia devoted to different functions exist. Therefore the aim of this review is to highlight the state of the art on NG2-glia heterogeneity from development to adulthood and in different brain areas, and discuss the impact of it on our understanding of the glial neurobiology. This article is part of a Special Issue entitled SI:NG2-glia(Invited only).
在中枢神经系统中，NG2胶质细胞是在发育和成年期负责生成成熟少突胶质细胞的细胞。一些研究表明，NG2胶质细胞也可以产生星形胶质细胞和神经元，这一特性使它们类似于神经干细胞。除了作为祖细胞的重要作用外，由于NG2胶质细胞通过突触与神经元的独特相互作用，人们认为它们还具有更多功能。然而，尚不清楚这些特征是否为所有NG2胶质细胞所共有，还是存在专门执行不同功能的NG2胶质细胞亚群。因此，本综述的目的是强调从发育到成年以及在不同脑区中NG2胶质细胞异质性的最新研究状况，并讨论其对我们理解胶质神经生物学的影响。本文是名为“SI：NG2胶质细胞（仅限特邀稿件）”特刊的一部分。
