少突胶质前体细胞在精神障碍中的典型和非典型作用。
Canonical and non-canonical roles of oligodendrocyte precursor cells in mental disorders.
作者信息
Poggi Giulia, Treccani Giulia, von der Bey Martina, Tanti Arnaud, Schmeisser Michael J, Müller Marianne
机构信息
Institute of Anatomy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
出版信息
Npj Ment Health Res. 2025 May 15;4(1):19. doi: 10.1038/s44184-025-00133-x.
Psychiatric research has shifted from a neuroncentric view to understanding mental disorders as disturbances of heterogeneous brain networks. Oligodendrocyte precursor cells (OPCs)- actively involved in the modulation of neuronal functions - are altered in psychiatric patients, but the extent and related consequences are unclear. This review explores canonical and non-canonical OPC-related pathways in schizophrenia, bipolar disorder, post-traumatic stress disorder, and depression in humans, highlighting potential mechanisms shared across diagnostic entities.
精神病学研究已从以神经元为中心的观点转向将精神障碍理解为异质性脑网络的紊乱。少突胶质前体细胞（OPCs）——积极参与神经元功能的调节——在精神疾病患者中发生改变，但程度和相关后果尚不清楚。本综述探讨了人类精神分裂症、双相情感障碍、创伤后应激障碍和抑郁症中与OPC相关的经典和非经典途径，强调了不同诊断实体之间共有的潜在机制。
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