红细胞分布宽度水平对社区获得性腹腔内脓毒症重症监护患者死亡率的预测价值。
The predictive value of red cell distribution width levels on mortality in intensive care patients with community-acquired intra-abdominal sepsis.
作者信息
Özdoğan Hatice Kaya, Karateke Faruk, Özyazıcı Sefa, Özdoğan Mehmet, Özaltun Pınar, Kuvvetli Adnan, Gökler Cihan, Ersoy Zeynep
机构信息
Department of Anesthesia and Reanimation, Adana Numune Training and Research Hospital, Adana, Turkey.
Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
出版信息
Ulus Travma Acil Cerrahi Derg. 2015 Sep;21(5):352-7. doi: 10.5505/tjtes.2015.26737.
BACKGROUND
Red cell distribution width (RDW) is a part of the complete blood count (CBC) panel reflecting quantitative measure of variability in the size of circulating red blood cells. It has been known that higher RDW is associated with increased mortality in several diseases. The aim of this study was to investigate the association between RDW and hospital mortality in intensive care unit (ICU) patients with community-acquired intra-abdominal sepsis (C-IAS).
METHODS
A retrospective analysis of the patients with C-IAS was performed between January 1, 2010 and March 31, 2013. Patients' demographics, co-morbidities, laboratory measures including RDW on admission to the ICU, and Acute Physiologic and Chronic Health Evaluation II (APACHE II) score were analyzed.
RESULTS
A total of one hundred and three patients with C-IAS were included into the study with a mean age of 64±14 years. Overall mortality was 50.5%. RDW day 1 (RDW1) values and APACHE II scores were significantly higher in non-survivors than in survivors. In multivariate analysis, only RDW1 and APACHE II predicted mortality. The area under the receiver operating curves (AUC) of RDW1 and APACHE II were 0.867 (95% CI, 0.791-0.942) and 0.943 (95% CI, 0.902-0.984), respectively.
CONCLUSION
This study suggests that increased RDW is associated with mortality in ICU patients with C-IAS.
背景
红细胞分布宽度（RDW）是全血细胞计数（CBC）的一部分，反映循环红细胞大小变异性的定量测量。已知在几种疾病中，较高的RDW与死亡率增加相关。本研究的目的是调查社区获得性腹腔内脓毒症（C-IAS）的重症监护病房（ICU）患者中RDW与医院死亡率之间的关联。
方法
对2010年1月1日至2013年3月31日期间患有C-IAS的患者进行回顾性分析。分析患者的人口统计学、合并症、包括入住ICU时的RDW在内的实验室指标以及急性生理与慢性健康状况评估II（APACHE II）评分。
结果
共有103例C-IAS患者纳入研究，平均年龄为64±14岁。总体死亡率为50.5%。非幸存者的第1天RDW（RDW1）值和APACHE II评分显著高于幸存者。在多变量分析中，只有RDW1和APACHE II可预测死亡率。RDW1和APACHE II的受试者工作曲线下面积（AUC）分别为0.867（95%CI，0.791-0.942）和0.943（95%CI，0.902-0.984）。
结论
本研究表明，RDW升高与C-IAS的ICU患者死亡率相关。
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