用于鉴定蛋白质聚集体的基于荧光噻吩的配体库
A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.
作者信息
Shirani Hamid, Linares Mathieu, Sigurdson Christina J, Lindgren Mikael, Norman Patrick, Nilsson K Peter R
机构信息
Division of Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
Division of Theoretical Chemistry, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping (Sweden).
出版信息
Chemistry. 2015 Oct 19;21(43):15133-7. doi: 10.1002/chem.201502999. Epub 2015 Sep 21.
By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.
通过用其他杂环部分取代阴离子五聚体低聚噻吩的中心噻吩单元，合成了一系列具有不同荧光特性的基于五聚体噻吩的配体。所有配体对重组淀粉样原纤维以及组织切片中与疾病相关的蛋白质聚集体均表现出优异的选择性。
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