Silachev D N, Plotnikov E Yu, Babenko V A, Danilina T I, Zorov L D, Pevzner I B, Zorov D B, Sukhikh G T
A. N. Belozersky Institute of Physicochemical Biology, Moscow, Russia.
Faculty and Bioengineering and Bioinformatics, Moscow, Russia.
Bull Exp Biol Med. 2015 Aug;159(4):528-33. doi: 10.1007/s10517-015-3009-3. Epub 2015 Sep 21.
We compared the efficiency of delivery of multipotent mesenchymal stem cells into the brain after their intravenous and intra-arterial injection. Analysis of the therapeutic effects of cells after experimental traumatic brain injury revealed improvement of the neurological status and motor functions of the damaged hemisphere, the effect being more pronounced after intraarterial injection of cells. Intra-arterial administration was followed by rapid infiltration of the cells into the brain tissue and their number considerably surpassed that after intravenous infusion. Targeted delivery of multipotent mesenchymal stromal cells into the brain after their injection into the carotid arteries substantially potentiated their neuroprotective effects in traumatic brain injury.
我们比较了多能间充质干细胞经静脉注射和动脉注射后进入大脑的递送效率。对实验性创伤性脑损伤后细胞治疗效果的分析显示，受损半球的神经状态和运动功能有所改善，动脉内注射细胞后的效果更为显著。动脉内给药后，细胞迅速渗入脑组织，其数量大大超过静脉输注后的数量。多能间充质基质细胞注入颈动脉后靶向递送至大脑，显著增强了其在创伤性脑损伤中的神经保护作用。
Zotero 插件