Bhave Sheila, Sapru Amita, Bavdekar Ashish, Kapatkar Vaibhavi, Mane Amey
Department of Pediatrics, KEM Hospital Research Centre, Pune; and *Department of Medical Affairs, Wockhardt Limited, Mumbai; India. Correspondence to: Dr Sheila Bhave, Department of Pediatrics, KEM Hospital Research Centre, Rasta Peth, Pune 411 011, India.
Indian Pediatr. 2015 Aug;52(8):687-90. doi: 10.1007/s13312-015-0697-8.
To assess immunogenicity of a single dose of live attenuated hepatitis A vaccine in Indian children, ten years after immunization.
Of 143 children vaccinated in 2004, 121 children were evaluated in 2014, clinically and for anti-HAV antibodies.
13 children were early vaccine failures who received two doses of HAV vaccine subsequently. 106 (98%) of 108 remaining children had seroprotective levels with a geometric mean titer of 100.5 mIU/mL. On analysis of all 121 children, the immunogenicity was 87.6%.
Single dose of live attenuated hepatitis A vaccine provides long-term immunity in Indian children.
评估单剂量甲型肝炎减毒活疫苗在印度儿童免疫接种十年后的免疫原性。
在2004年接种疫苗的143名儿童中，2014年对121名儿童进行了临床和抗甲型肝炎病毒（HAV）抗体评估。
13名儿童为早期疫苗接种失败者，随后接受了两剂HAV疫苗。其余108名儿童中的106名（98%）具有血清保护水平，几何平均滴度为100.5 mIU/mL。对所有121名儿童进行分析，免疫原性为87.6%。
单剂量甲型肝炎减毒活疫苗可为印度儿童提供长期免疫力。
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