甲型肝炎活疫苗的长期免疫原性和耐受性综述。
Review of long term immunogenicity and tolerability of live hepatitis A vaccine.
作者信息
Shah Nitin, Faridi Mma, Mitra Monjori, Bavdekar Ashish, Karadkhele Archana, Puppalwar Gaurav, Jain Rishi
机构信息
Pediatrics Department, PD Hinduja Hospital , Mumbai, India.
Pediatrics Department, ERA's Lucknow Medical College & Hospital , Lucknow, India.
出版信息
Hum Vaccin Immunother. 2020 Nov 1;16(11):2816-2821. doi: 10.1080/21645515.2020.1741997. Epub 2020 Apr 3.
Abstract
Hepatitis A represents one of the major public health problems worldwide including India. Vaccination is the most effective way to prevent hepatitis A infection. Two types of hepatitis A vaccines-live attenuated (H2 strain) and inactivated (killed) are available for use in clinical practice in India with former having advantage of a single-dose compared to two-dose killed vaccine. One of the important characteristic of an ideal vaccine includes its ability to provide life-long protection. In this article we reviewed the available long-term (≥10 years follow-up) published data on live attenuated hepatitis A (H2 strain) vaccine. The data from country of origin of the vaccine (China) and India establish the long-term immunogenicity, protection, and tolerability. Based on the results of several clinical trials showing long-term protection, single dose of live attenuated hepatitis vaccine can be widely used to protect high-risk population against hepatitis A virus infection and related complications.
摘要
甲型肝炎是包括印度在内的全球主要公共卫生问题之一。接种疫苗是预防甲型肝炎感染的最有效方法。在印度临床实践中可使用两种甲型肝炎疫苗——减毒活疫苗（H2株）和灭活（死）疫苗，与两剂次的灭活疫苗相比，前者具有单剂次接种的优势。理想疫苗的一个重要特性包括其提供终身保护的能力。在本文中，我们回顾了已发表的关于甲型肝炎减毒活疫苗（H2株）的长期（≥10年随访）数据。来自疫苗原产国（中国）和印度的数据证实了其长期免疫原性、保护作用和耐受性。基于多项显示长期保护作用的临床试验结果，单剂次甲型肝炎减毒活疫苗可广泛用于保护高危人群免受甲型肝炎病毒感染及相关并发症。
相似文献
1
Review of long term immunogenicity and tolerability of live hepatitis A vaccine.甲型肝炎活疫苗的长期免疫原性和耐受性综述。
Hum Vaccin Immunother. 2020 Nov 1;16(11):2816-2821. doi: 10.1080/21645515.2020.1741997. Epub 2020 Apr 3.
2
A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children.儿童甲型肝炎减毒活疫苗的免疫原性和耐受性综述。
Hum Vaccin Immunother. 2016 Dec;12(12):3160-3165. doi: 10.1080/21645515.2016.1216286.
3
Comparing live attenuated and inactivated hepatitis A vaccines: an immunogenicity study after one single dose.比较活疫苗和灭活疫苗：单次接种后的免疫原性研究。
Vaccine. 2011 Nov 8;29(48):9098-103. doi: 10.1016/j.vaccine.2011.08.078. Epub 2011 Aug 27.
4
Comparison of the safety and immunogenicity of live attenuated and inactivated hepatitis A vaccine in healthy Chinese children aged 18 months to 16 years: results from a randomized, parallel controlled, phase IV study.18 个月至 16 岁健康中国儿童中减毒活疫苗和灭活疫苗的安全性和免疫原性比较：一项随机、平行对照、四期研究结果。
Clin Microbiol Infect. 2016 Sep;22(9):811.e9-811.e15. doi: 10.1016/j.cmi.2016.06.004. Epub 2016 Jun 23.
5
Development, production, and postmarketing surveillance of hepatitis A vaccines in China.中国甲型肝炎疫苗的研发、生产和上市后监测。
J Epidemiol. 2014;24(3):169-77. doi: 10.2188/jea.je20130022. Epub 2014 Mar 29.
6
Comparison of Immunogenicity Between Inactivated and Live Attenuated Hepatitis A Vaccines Among Young Adults: A 3-Year Follow-up Study.青年成人中灭活甲肝疫苗与减毒活甲肝疫苗免疫原性的比较：一项3年随访研究。
J Infect Dis. 2015 Oct 15;212(8):1232-6. doi: 10.1093/infdis/jiv213. Epub 2015 May 12.
7
Comparison of immunogenicity between inactivated and live attenuated hepatitis A vaccines: a single-blind, randomized, parallel-group clinical trial among children in Xinjiang Uighur Autonomous Region, China.中国新疆维吾尔自治区儿童中使用灭活和减毒甲型肝炎疫苗的免疫原性比较：一项单盲、随机、平行组临床试验。
Hum Vaccin Immunother. 2013 Jul;9(7):1460-5. doi: 10.4161/hv.24366. Epub 2013 Apr 9.
8
[Immune response to one booster dose of inactivated hepatitis A vaccine in college students].[大学生对一剂甲型肝炎灭活疫苗加强针的免疫反应]
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 May 10;38(5):625-628. doi: 10.3760/cma.j.issn.0254-6450.2017.05.013.
9
[Evaluation on the effect of immunization and safety of live attenuated and inactivated hepatitis A vaccine in China].[中国甲型肝炎减毒活疫苗与灭活疫苗免疫效果及安全性评价]
Zhonghua Liu Xing Bing Xue Za Zhi. 2013 Jan;34(1):24-7.
10
Long-term immunogenicity of single dose of live attenuated hepatitis A vaccine in Indian children.单剂量甲型肝炎减毒活疫苗在印度儿童中的长期免疫原性。
Indian Pediatr. 2015 Aug;52(8):687-90. doi: 10.1007/s13312-015-0697-8.
引用本文的文献
1
Expert consensus and recommendations on the live attenuated hepatitis A vaccine and immunization practices in India.印度甲型肝炎减毒活疫苗及免疫实践专家共识与建议
Hum Vaccin Immunother. 2025 Dec;21(1):2447643. doi: 10.1080/21645515.2024.2447643. Epub 2025 Jan 16.
2
Cellular immune response to a single dose of live attenuated hepatitis a virus vaccine in obese children and adolescents.肥胖儿童和青少年对单剂量甲型肝炎减毒活疫苗的细胞免疫反应。
Heliyon. 2024 Aug 20;10(16):e36610. doi: 10.1016/j.heliyon.2024.e36610. eCollection 2024 Aug 30.
3
Identification of mutations in viral proteins involved in cell adaptation using a reverse genetic system of the live attenuated hepatitis A virus vaccine H2 strain.利用减毒活甲型肝炎病毒疫苗H2株的反向遗传系统鉴定参与细胞适应性的病毒蛋白中的突变。
Virol Sin. 2024 Dec;39(6):882-891. doi: 10.1016/j.virs.2024.08.004. Epub 2024 Aug 14.
4
Hepatitis a Vaccine as Opportunity of Primary Prevention for Food Handlers: A Narrative Review.甲型肝炎疫苗：食品从业人员一级预防的契机——一项叙述性综述
Vaccines (Basel). 2023 Jul 21;11(7):1271. doi: 10.3390/vaccines11071271.
5
Recent Advances in Protective Vaccines against Hepatitis Viruses: A Narrative Review.近年来肝炎病毒保护性疫苗的研究进展：叙述性综述。
Viruses. 2023 Jan 12;15(1):214. doi: 10.3390/v15010214.
6
The infectivity and pathogenicity of hepatitis A virus live-attenuated vaccine strain H2 in type I interferon receptor-deficient mice.甲型肝炎病毒活疫苗株 H2 在 I 型干扰素受体缺陷型小鼠中的感染性和致病性。
Virol Sin. 2022 Oct;37(5):740-745. doi: 10.1016/j.virs.2022.07.009. Epub 2022 Jul 19.
7
The Safety, Immunogenicity, and Immunopersistence of Hepatitis A Vaccine in HBs-Ag-Positive Participants: A Retrospective Study.在 HBs-Ag 阳性参与者中甲型肝炎疫苗的安全性、免疫原性和免疫持久性：一项回顾性研究。
Front Cell Infect Microbiol. 2021 Jun 17;11:672221. doi: 10.3389/fcimb.2021.672221. eCollection 2021.
8
Long term Immunogenicity of Single Dose of Live Attenuated Hepatitis A Vaccine in Indian Children - Results of 15-Year Follow-up.单次剂量活疫苗在印度儿童中的长期免疫原性 - 15 年随访结果。
Indian Pediatr. 2021 Aug 15;58(8):749-752. doi: 10.1007/s13312-021-2285-4. Epub 2021 Feb 19.
9
Food products as potential carriers of SARS-CoV-2.食品作为严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的潜在载体。
Food Control. 2021 May;123:107754. doi: 10.1016/j.foodcont.2020.107754. Epub 2020 Nov 11.
本文引用的文献
1
Comparison of chemiluminescence enzyme immunoassay based on magnetic microparticles with traditional colorimetric ELISA for the detection of serum α-fetoprotein.基于磁性微粒的化学发光酶免疫分析法与传统比色酶联免疫吸附测定法检测血清甲胎蛋白的比较
J Pharm Anal. 2012 Apr;2(2):130-135. doi: 10.1016/j.jpha.2011.10.001. Epub 2012 Jan 27.
2
Immune memory at 17-years of follow-up of a single dose of live attenuated hepatitis A vaccine.单次接种甲型肝炎减毒活疫苗后 17 年的免疫记忆。
Vaccine. 2018 Jan 2;36(1):114-121. doi: 10.1016/j.vaccine.2017.11.036. Epub 2017 Nov 26.
3
A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children.儿童甲型肝炎减毒活疫苗的免疫原性和耐受性综述。
Hum Vaccin Immunother. 2016 Dec;12(12):3160-3165. doi: 10.1080/21645515.2016.1216286.
4
Long-term immunogenicity of single dose of live attenuated hepatitis A vaccine in Indian children.单剂量甲型肝炎减毒活疫苗在印度儿童中的长期免疫原性。
Indian Pediatr. 2015 Aug;52(8):687-90. doi: 10.1007/s13312-015-0697-8.
5
Long-term antibody persistence after vaccination with a 2-dose Havrix (inactivated hepatitis A vaccine): 20 years of observed data, and long-term model-based predictions.接种两剂Havrix（甲型肝炎灭活疫苗）后的长期抗体持久性：20年观察数据及基于模型的长期预测
Vaccine. 2015 Oct 13;33(42):5723-5727. doi: 10.1016/j.vaccine.2015.07.008. Epub 2015 Jul 16.
6
Long term follow-up study to evaluate immunogenicity and safety of a single dose of live attenuated hepatitis a vaccine in children.评估儿童单剂量甲型肝炎减毒活疫苗免疫原性和安全性的长期随访研究
Hum Vaccin Immunother. 2015;11(5):1147-52. doi: 10.4161/21645515.2014.979646.
7
Changing hepatitis A epidemiology in the European Union: new challenges and opportunities.改变欧盟的甲型肝炎流行病学：新的挑战和机遇。
Euro Surveill. 2015 Apr 23;20(16):21101. doi: 10.2807/1560-7917.es2015.20.16.21101.
8
Indian Academy of Pediatrics (IAP) recommended immunization schedule for children aged 0 through 18 years--India, 2014 and updates on immunization.印度儿科学会（IAP）针对0至18岁儿童的推荐免疫接种计划——印度，2014年及免疫接种更新情况
Indian Pediatr. 2014 Oct;51(10):785-800. doi: 10.1007/s13312-014-0504-y.
9
Era of vaccination heralds a decline in incidence of hepatitis A in high-risk groups in China.疫苗接种时代预示着中国高危人群中甲肝发病率的下降。
Hepat Mon. 2012 Feb;12(2):100-5. doi: 10.5812/hepatmon.838. Epub 2012 Feb 29.
10
Hepatitis A: Epidemiology and prevention in developing countries.甲型肝炎：发展中国家的流行病学与预防
World J Hepatol. 2012 Mar 27;4(3):68-73. doi: 10.4254/wjh.v4.i3.68.
Zotero 插件