Koganei Megumi, Saitou Yuri, Tsuchiya Kyoko, Abe Fuminori, Tanaka Toru, Horinouchi Izumi, Izumi Yoshiya, Yamaji Taketo, Takahashi Takeshi
Nutrition Research Department, Food Science Research Laboratories, Meiji Co., Ltd., 540 Naruda, Odawara, Kanagawa 250-0862, Japan.
SBI Pharma Co., Ltd., Izumi Garden Tower 20F, 1-6-1 Roppongi, Minato, Tokyo 106-6020, Japan.
J Clin Biochem Nutr. 2015 Sep;57(2):145-50. doi: 10.3164/jcbn.13-58. Epub 2015 Jul 11.
The effects of 5-aminolevulinic acid (5-ALA) on obesity were investigated using a murine model (diet-induced obese mice). Diet-induced obese mice were divided into 4 groups: a control group (C group), which was fed a high-fat diet; a low-5-ALA dose (10 mg/kg/day) group (10A group); a moderate-5-ALA dose (30 mg/kg/day) group (30A group); and a high-5-ALA dose (100 mg/kg/day) group (100A group). 5-ALA was administered by mixing the high fat diet for 8 weeks. Body weight increases in the 30A and 100A groups were significantly smaller compared with those of the C group. Body fat measurements by X-ray computed tomography indicated that the 100A group showed a tendency toward low visceral fat quantities during the final week of the study. Visceral fat weights in the 30A and 100A groups were slightly low. The levels of serum alanine aminotransferase (ALT) and total cholesterol (TC) in the 10A group was slightly low, whereas the 30A and 100A groups showed significantly lower ALT and TC values. Liver lipid concentration showed a dose-dependent decrease with ALA. Thus, in this diet-induced obese murine model, administration of 5-ALA had a significantly beneficial impact on the visceral fat, serum ALT and TC, and liver lipid concentration.
使用小鼠模型（饮食诱导肥胖小鼠）研究了5-氨基乙酰丙酸（5-ALA）对肥胖的影响。饮食诱导肥胖小鼠分为4组：对照组（C组），喂食高脂饮食；低剂量5-ALA组（10毫克/千克/天）（10A组）；中剂量5-ALA组（30毫克/千克/天）（30A组）；高剂量5-ALA组（100毫克/千克/天）（100A组）。通过将5-ALA混入高脂饮食中进行给药，持续8周。与C组相比，30A组和100A组的体重增加明显较小。X射线计算机断层扫描测量体脂表明，在研究的最后一周，100A组显示出内脏脂肪量较低的趋势。30A组和100A组的内脏脂肪重量略低。10A组的血清丙氨酸氨基转移酶（ALT）和总胆固醇（TC）水平略低，而30A组和100A组的ALT和TC值显著较低。肝脏脂质浓度随ALA呈剂量依赖性降低。因此，在这种饮食诱导肥胖的小鼠模型中，给予5-ALA对内脏脂肪、血清ALT和TC以及肝脏脂质浓度具有显著的有益影响。
