Sakai Aki, Iwatani Nao, Harada Kazuki
One Health Business Department, Neopharma Japan Co., Ltd., Tokyo 102-0071, Japan.
Anchor Trust Animal Hospital, Tokyo.
Yonago Acta Med. 2020 Jul 10;63(3):234-238. doi: 10.33160/yam.2020.08.006. eCollection 2020 Aug.
This is the first study to examine the long-term effect of 5-aminolevulinic acid mainly on serum lipoproteins in dogs with hyperlipidemia. We studied 5 Miniature Schnauzer cases whose fasting serum total triglyceride and very-low-density lipoprotein of triglyceride levels were extremely high (635 ± 116 and 520 ± 92 mg/dL, respectively). Although the total cholesterol values were normal, the very-low-density lipoprotein of cholesterol level was high (49 ± 7 mg/dL). Each dog received a 5-aminolevulinic acid supplement (5 mg/day) orally for 6 months. The mean values of total triglyceride, very-low-density lipoprotein of both triglyceride and cholesterol decreased significantly after the treatment period (319 ± 29, 245 ± 18, and 27 ± 2 mg/dL, respectively, < 0.05). Our present results may present evidence that 5-ALA administration contributes to improvement of hyperlipidemia in Miniature Schnauzer.
这是第一项主要研究5-氨基乙酰丙酸对高脂血症犬血清脂蛋白长期影响的研究。我们研究了5例迷你雪纳瑞犬，其空腹血清总甘油三酯和极低密度脂蛋白甘油三酯水平极高（分别为635±116和520±92mg/dL）。尽管总胆固醇值正常，但极低密度脂蛋白胆固醇水平较高（49±7mg/dL）。每只犬口服5-氨基乙酰丙酸补充剂（5mg/天），持续6个月。治疗期后，总甘油三酯、甘油三酯和胆固醇的极低密度脂蛋白的平均值显著下降（分别为319±29、245±18和27±2mg/dL，P<0.05）。我们目前的结果可能表明，给予5-氨基乙酰丙酸有助于改善迷你雪纳瑞犬的高脂血症。
