单细胞分析揭示了Bcl11a在调节干细胞命运决定中的关键作用。
Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions.
作者信息
Powers Ashley N, Satija Rahul
机构信息
New York Genome Center, New York, NY, 10012, USA.
New York University, Center for Genomics and Systems Biology, New York, NY, 10012, USA.
出版信息
Genome Biol. 2015 Sep 21;16(1):199. doi: 10.1186/s13059-015-0778-y.
Abstract
Cell-cycle fluctuations drive significant transcriptomic heterogeneity in murine hematopoietic stem cells. Additionally, deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice.
摘要
细胞周期波动驱动小鼠造血干细胞中显著的转录组异质性。此外，Bcl11a的缺失会改变造血干细胞静止、自我更新和命运选择的调控。
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