高盐摄入与高血压靶器官损害独立相关。
High Salt Intake Is Independently Associated With Hypertensive Target Organ Damage.
作者信息
Imaizumi Yuki, Eguchi Kazuo, Murakami Takeshi, Arakawa Kimika, Tsuchihashi Takuya, Kario Kazuomi
机构信息
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Munakata Ohshima Clinic, Munakata, Fukuoka, Japan.
出版信息
J Clin Hypertens (Greenwich). 2016 Apr;18(4):315-21. doi: 10.1111/jch.12668. Epub 2015 Sep 22.
Abstract
The authors tested the hypothesis that high salt intake is associated with hypertensive target organ damage (TOD) independent of blood pressure (BP), and oxidative stress is a modifying factor of this association. A total of 369 community-dwelling Japanese adults (mean age, 67.5 years; 56.6% women) were examined in this observational study. At the patients' annual health check-ups, urinary salt excretion (U-SALT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and albumin-creatinine ratio (UACR) were measured from first morning urine. U-SALT (β=0.14, P=.016) and 8-OHdG (β=0.13, P=.018) were both independently associated with logUACR. U-SALT was associated with TOD independent of BP level, and oxidative stress may be a modifying factor in the association between high salt intake and TOD. The elevation of 8-OHdG may be involved in the pathophysiology of TOD induced by salt intake.
摘要
作者检验了以下假设
高盐摄入与高血压靶器官损害（TOD）相关，且独立于血压（BP），氧化应激是这种关联的修饰因素。在这项观察性研究中，共检查了369名居住在社区的日本成年人（平均年龄67.5岁；女性占56.6%）。在患者的年度健康检查中，从晨尿中测量尿盐排泄量（U-SALT）、8-羟基-2'-脱氧鸟苷（8-OHdG）和白蛋白-肌酐比值（UACR）。U-SALT（β=0.14，P=0.016）和8-OHdG（β=0.13，P=0.018）均与logUACR独立相关。U-SALT与TOD相关，且独立于血压水平，氧化应激可能是高盐摄入与TOD之间关联的修饰因素。8-OHdG的升高可能参与了盐摄入诱导的TOD的病理生理过程。
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本文引用的文献
1
Dietary sodium and health: more than just blood pressure.
J Am Coll Cardiol. 2015 Mar 17;65(10):1042-50. doi: 10.1016/j.jacc.2014.12.039.
2
The pathophysiological role of interstitial sodium in heart failure.
J Am Coll Cardiol. 2015 Feb 3;65(4):378-388. doi: 10.1016/j.jacc.2014.11.025.
3
Increased arterial blood pressure and vascular remodeling in mice lacking salt-inducible kinase 1 (SIK1).
Circ Res. 2015 Feb 13;116(4):642-52. doi: 10.1161/CIRCRESAHA.116.304529. Epub 2015 Jan 2.
4
Vascular effects of dietary salt.
Curr Opin Nephrol Hypertens. 2015 Jan;24(1):8-13. doi: 10.1097/MNH.0000000000000089.
5
Higher dietary salt intake is associated with microalbuminuria, but not with retinopathy in individuals with type 1 diabetes: the EURODIAB Prospective Complications Study.
Diabetologia. 2014 Nov;57(11):2315-23. doi: 10.1007/s00125-014-3367-9. Epub 2014 Aug 30.
6
Global sodium consumption and death from cardiovascular causes.
N Engl J Med. 2014 Aug 14;371(7):624-34. doi: 10.1056/NEJMoa1304127.
7
Validation and comparison of three formulae to estimate sodium and potassium excretion from a single morning fasting urine compared to 24-h measures in 11 countries.
J Hypertens. 2014 May;32(5):1005-14; discussion 1015. doi: 10.1097/HJH.0000000000000122.
8
Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes.
Hypertension. 2014 Apr;63(4):797-803. doi: 10.1161/HYPERTENSIONAHA.113.02883. Epub 2014 Jan 13.
9
Lower levels of sodium intake and reduced cardiovascular risk.
Circulation. 2014 Mar 4;129(9):981-9. doi: 10.1161/CIRCULATIONAHA.113.006032. Epub 2014 Jan 10.
10
Epithelial sodium channel inhibition by amiloride on blood pressure and cardiovascular disease risk in young prehypertensives.
J Clin Hypertens (Greenwich). 2014 Jan;16(1):47-53. doi: 10.1111/jch.12218. Epub 2013 Oct 31.
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