法国囊性纤维化患者的死亡原因：需要改进移植转诊策略！
Causes of death in French cystic fibrosis patients: The need for improvement in transplantation referral strategies!
机构信息
Department of Respiratory Medicine, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Department of Cardiac Surgery, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
出版信息
J Cyst Fibros. 2016 Mar;15(2):204-12. doi: 10.1016/j.jcf.2015.09.002. Epub 2015 Sep 26.
BACKGROUND
Little data exist on causes of death in cystic fibrosis (CF) patients in the era of lung transplantation.
METHODS
Deaths in CF patients in France (2007-2010) were identified using the French CF Registry and causes of deaths were determined based on medical files by a mortality adjudication committee.
RESULTS
Of 256 deaths, half occurred after lung transplantation and were related to early or late complications of transplantation, whereas half occurred in patients who did not receive lung transplantation and were primarily related to respiratory failure or massive hemoptysis. Among patients who did not receive lung transplantation, only 19% died while waiting on a lung transplantation list. Lack of listing for lung transplantation was primarily related to late, or to lack of transplantation referral, rather than to contraindication to transplantation.
CONCLUSIONS
These data suggest that improvement in transplantation referral strategies may result in transplantation-related survival benefits.
背景
在肺移植时代，囊性纤维化（CF）患者的死亡原因数据很少。
方法
使用法国 CF 登记处确定法国 CF 患者的死亡人数，并通过死亡率裁决委员会根据病历确定死亡原因。
结果
在 256 例死亡中，有一半发生在肺移植后，与移植的早期或晚期并发症有关，而另一半发生在未接受肺移植的患者中，主要与呼吸衰竭或大咯血有关。在未接受肺移植的患者中，只有 19%的患者在等待肺移植名单时死亡。未列入肺移植名单的主要原因是移植推荐延迟或缺乏移植推荐，而不是移植禁忌。
结论
这些数据表明，改善移植推荐策略可能会带来与移植相关的生存获益。
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