含1.5%伊维菌素+0.5%阿维菌素的浇泼剂在牛体内的体内外寄生虫驱杀活性
Endectocide activity of a pour-on formulation containing 1.5 per cent ivermectin +0.5 per cent abamectin in cattle.
作者信息
Silva Heloisa Cristina, Prette Nancy, Lopes Welber Daniel Zanetti, Sakamoto Cláudio Alessandro M, Buzzulini Carolina, Dos Santos Thais Rabelo, Cruz Breno Cayeiro, Teixeira Weslen F Pires, Felippelli Gustavo, Carvalho Rafael Silveira, Maciel Willian Giquelin, Soares Vando Edésio, da Costa Alvimar José
机构信息
Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil ; Department of Veterinary Medicine, Instituto de Ciência da Saúde da Universidade Federal da Bahia Salvador-Bahia, Brazil.
Department of Animal Pathology, Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Via de acesso prof. Paulo Donatto Castellani , Jaboticabal, São Paulo , Brazil ; Departament of Veterinary Medicine, Universidade Federal da Paraíba - Campus II, Brazil.
出版信息
Vet Rec Open. 2015 Jun 27;2(1):e000072. doi: 10.1136/vetreco-2014-000072. eCollection 2015.
The present work aimed to evaluate, through ten different studies, the therapeutic efficacy of a new pour-on formulation, containing 1.5 per cent ivermectin +0.5 per cent abamectin, against parasites of cattle. Results obtained on trials against Rhipicephalus (Boophilus) microplus showed that the pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained superior efficacy indexes against this ectoparasite, when compared with formulations containing 0.5 per cent ivermectin, 1 per cent ivermectin and the combination of 1 per cent abamectin +20 per cent levamisole. The results of efficacy of the ivermectin+abamectin and the 0.5 per cent ivermectin against Haematobia irritans were similar. Against Cochliomyia hominivorax larvae, all pour-on formulations tested (1.5 per cent ivermectin +0.5 per cent abamectin, 0.5 per cent ivermectin and 0.5 per cent abamectin), as well as 1 per cent doramectin administered subcutaneously, were considered ineffective. Cattle medicated with 1.5 per cent ivermectin +0.5 per cent abamectin, pour-on, remained free from parasitism by Dermatobia hominis larvae during 42 days (96 per cent efficacy), while values superior to 90 per cent were obtained by 0.5 per cent ivermectin (92 per cent) and 0.5 per cent abamectin (93 per cent) until the 42nd and 35th days post treatment, respectively. Against Haemonchus placei and Oesophagostomum radiatum, the pour-on of ivermectin+abamectin showed better efficacy than the 0.5 per cent ivermectin and 0.5 per cent abamectin. As to Cooperia punctata, there was no difference regarding efficacy results obtained by the avermectins combination and abamectin. The pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained high efficacy against R. (B.) microplus, D. hominis and some species of cattle gastrointestinal helminths when compared with formulations of 0.5 per cent ivermectin and 0.5 per cent abamectin administered through the same route.
本研究旨在通过十项不同的研究，评估一种含有1.5%伊维菌素+0.5%阿维菌素的新型浇泼剂配方对牛寄生虫的治疗效果。针对微小牛蜱（Rhipicephalus (Boophilus) microplus）的试验结果表明，与含有0.5%伊维菌素、1%伊维菌素以及1%阿维菌素+20%左旋咪唑组合的配方相比，1.5%伊维菌素+0.5%阿维菌素的浇泼剂组合对这种体外寄生虫具有更高的疗效指标。伊维菌素+阿维菌素与0.5%伊维菌素对血蝇（Haematobia irritans）的疗效结果相似。针对人肤蝇（Cochliomyia hominivorax）幼虫，所有测试的浇泼剂配方（1.5%伊维菌素+0.5%阿维菌素、0.5%伊维菌素和0.5%阿维菌素）以及皮下注射的1%多拉菌素均被认为无效。用1.5%伊维菌素+0.5%阿维菌素浇泼剂处理的牛在42天内未感染人皮蝇（Dermatobia hominis）幼虫（疗效为96%），而0.5%伊维菌素（92%）和0.5%阿维菌素（93%）分别在治疗后第42天和第35天获得了高于90%的疗效值。针对牛血矛线虫（Haemonchus placei）和辐射食道口线虫（Oesophagostomum radiatum），伊维菌素+阿维菌素浇泼剂的疗效优于0.5%伊维菌素和0.5%阿维菌素。对于点状库珀线虫（Cooperia punctata），阿维菌素组合和阿维菌素的疗效结果没有差异。与通过相同途径给药的0.5%伊维菌素和0.5%阿维菌素配方相比，1.5%伊维菌素+0.5%阿维菌素的浇泼剂组合对微小牛蜱、人皮蝇和一些牛胃肠道蠕虫具有高效。
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