在印度的项目条件下，漂白沉淀涂片显微镜检查能否替代直接显微镜检查？
Is bleach-sedimented smear microscopy an alternative to direct microscopy under programme conditions in India?
作者信息
Vishnu P H, Bhat P, Bansal A, Satyanarayana S, Alavadi U, Ohri B S, Shrinivas M S Rao, Desikan P, Jaju J, Rao V G, Moonan P K
机构信息
State Tuberculosis Training and Demonstration Centre, Hyderabad, Andra Pradesh, India.
World Health Organization Revised National Tuberculosis Control Programme (RNTCP) Technical Assistance Project, New Delhi, India.
出版信息
Public Health Action. 2013 Mar 21;3(1):23-5. doi: 10.5588/pha.12.0100.
This cross-sectional multi-centric study compared the yield of and potential benefit for detecting smear-positive pulmonary tuberculosis (PTB) by bleach sedimentation (2% sodium-hypochlorite) versus direct microscopy under programme conditions in India. Among 3168 PTB suspects, 684 (21.6%) were detected by bleach sedimentation vs. 625 (19.7%) by direct microscopy, with a proportional overall agreement of 96% (κ = 0.88). While 594 patients were smear-positive with both methods, 31 patients detected by direct microscopy were missed and an additional 90 patients were detected by bleach sedimentation. Overall, bleach sedimentation increased the yield of smear-positive TB detection; however; it also increased the time to results.
这项横断面多中心研究比较了在印度的项目条件下，采用漂白剂沉淀法（2%次氯酸钠）与直接显微镜检查法检测涂片阳性肺结核（PTB）的检出率和潜在益处。在3168名PTB疑似患者中，漂白剂沉淀法检测出684例（21.6%），直接显微镜检查法检测出625例（19.7%），总体比例一致性为96%（κ = 0.88）。两种方法均检测出594例涂片阳性患者，直接显微镜检查法漏检了31例患者，漂白剂沉淀法额外检测出90例患者。总体而言，漂白剂沉淀法提高了涂片阳性结核病的检出率；然而，它也增加了出结果的时间。
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