State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 200050, Shanghai, P. R. China.
Second Affiliated Hospital of Chongqing Medical University, 400016, Chongqing, P. R. China.
Adv Mater. 2015 Nov 4;27(41):6382-9. doi: 10.1002/adma.201503381. Epub 2015 Sep 22.
Novel core-shell hollow mesoporous Prussian blue @ Mn-containing Prussian blue analogue (HMPB@MnPBA) nanoparticles, designated as HMPB-Mn) as an intelligent theranostic nanoagent, are successfully constructed by coating a similarly crystal-structured MnPBA onto HMPB. This can be used as a pH-responsive T1 -weighted magnetic resonance imaging contrast agent with ultrahigh longitudinal relaxivity (r1 = 7.43 m m(-1) s(-1) ), and achieves the real-time monitoring of drug release.
新型核壳中空介孔普鲁士蓝@含锰普鲁士蓝类似物（HMPB@MnPBA）纳米粒子，命名为 HMPB-Mn），作为一种智能治疗诊断纳米试剂，通过将具有相似晶体结构的 MnPBA 涂覆在 HMPB 上成功构建。它可用作 pH 响应性 T1 加权磁共振成像对比剂，具有超高的纵向弛豫率（r1 = 7.43 m m-1 s-1），并实现了药物释放的实时监测。
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