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NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity.

作者信息

Li Qianzhe, Yang Mengyu, Sun Xin, Wang Qinxin, Yu Beibei, Gong Aihua, Zhang Miaomiao, Du Fengyi

机构信息

Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University 212013, PR. China.

Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, PR. China.

出版信息

Mater Today Bio. 2023 Jan 29;19:100566. doi: 10.1016/j.mtbio.2023.100566. eCollection 2023 Apr.

DOI:10.1016/j.mtbio.2023.100566
PMID:36816600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9932208/
Abstract

Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB-Mn/OVA NE) was constructed by doping manganese into the ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity to produce oxygen, which was conducive to alleviate the tumor hypoxic microenvironment. Under 808 ​nm NIR irradiation, the PB-Mn/OVA NEs with outstanding photothermal conversion efficiency of 30% significantly destroyed tumor cells by inducing immunogenic cell death (ICD). Impressively, the PB-Mn/OVA NEs could activate the cGAS-STING pathway to promote the maturation and the antigen cross-presentation ability of dendritic cells (DCs), which further activated cytotoxic T lymphocytes and memory T lymphocytes. Overall, this work presents a powerful nanoenzyme formula to integrate photothermal ablation and hypoxic reversal for triggering robust innate and adaptive antitumor immune response.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/af28e018b3d7/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/599319a41697/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/d2a3a9477e59/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/e277f596e5a9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/fc1a95e33614/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/6099eee80431/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/4981fa6aec81/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/ac0ddb2d00ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/d7562a246cf7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/45a36a1ed18e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/af28e018b3d7/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/599319a41697/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/d2a3a9477e59/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/e277f596e5a9/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/fc1a95e33614/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/6099eee80431/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/4981fa6aec81/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/ac0ddb2d00ca/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/d7562a246cf7/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/45a36a1ed18e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a630/9932208/af28e018b3d7/gr8.jpg

相似文献

[1]
NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity.

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[8]
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[9]
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引用本文的文献

[1]
Manganese-Based Nanotherapeutics for Targeted Treatment of Breast Cancer.

ACS Appl Bio Mater. 2025-5-19

[2]
Dual-modality immune nano-activator harnessing Mn⁺ and quercetin to potentiate the cGAS-STING pathway for advanced cancer metalloimmunotherapy.

J Nanobiotechnology. 2025-3-25

[3]
Orchestrating cancer therapy: Recent advances in nanoplatforms harmonize immunotherapy with multifaceted treatments.

Mater Today Bio. 2024-12-9

[4]
Targeted regulation of autophagy using sorafenib-loaded biomineralization nanoenzyme for enhanced photodynamic therapy of hepatoma.

Mater Today Bio. 2024-9-24

[5]
Mn-phenolic networks as synergistic carrier for STING agonists in tumor immunotherapy.

Mater Today Bio. 2024-3-11

[6]
Endogenous HO Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy.

Int J Nanomedicine. 2023

本文引用的文献

[1]
Manganese Coordination Micelles That Activate Stimulator of Interferon Genes and Capture In Situ Tumor Antigens for Cancer Metalloimmunotherapy.

ACS Nano. 2022-10-25

[2]
Fabrication of methylene blue-loaded ovalbumin/polypyrrole nanoparticles for enhanced phototherapy-triggered antitumour immune activation.

J Nanobiotechnology. 2022-6-22

[3]
Biomimetic manganese-based theranostic nanoplatform for cancer multimodal imaging and twofold immunotherapy.

Bioact Mater. 2022-4-20

[4]
Hybrid-Membrane-Decorated Prussian Blue for Effective Cancer Immunotherapy via Tumor-Associated Macrophages Polarization and Hypoxia Relief.

Adv Mater. 2022-4

[5]
Photothermal-triggered immunogenic nanotherapeutics for optimizing osteosarcoma therapy by synergizing innate and adaptive immunity.

Biomaterials. 2022-3

[6]
Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification.

Small. 2021-11

[7]
Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy.

Nat Nanotechnol. 2021-11

[8]
Molecular Mechanism and Prevention Strategy of Chemotherapy- and Radiotherapy-Induced Ovarian Damage.

Int J Mol Sci. 2021-7-13

[9]
NIR responsive tumor vaccine in situ for photothermal ablation and chemotherapy to trigger robust antitumor immune responses.

J Nanobiotechnology. 2021-5-17

[10]
Targeting Innate Immunity in Cancer Therapy.

Vaccines (Basel). 2021-2-9

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