Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Acta Biomater. 2016 Jan;30:378-387. doi: 10.1016/j.actbio.2015.11.036. Epub 2015 Nov 18.
UNLABELLED: A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relatively low hydrothermal temperature and alkali-free condition. The mesoporous manganese silicate shell provides a large specific surface area and abundant exposed Mn paramagnetic centers to water molecules, which endows the MMSSNs with extraordinarily high longitudinal relaxivity. Meanwhile, the MMSSNs presented an efficient pH/redox-responsive T1-MRI feature based on the significant enhancement of relaxation rate (r1) stimulated by mild acidic environment or reducing agent (GSH) both in vitro and in vivo. Furthermore, the mesoporous structure and negatively charged pore surface of the manganese silicate shell enable the MMSSNs to attain anti-cancer drug (DOX) storage and a pH-responsive release, which is suitable for on-demand drug release for the chemotherapy of tumors. Therefore, the mesoporous manganese silicate-based nanomaterial is a promising candidate as T1-MRI CAs and anticancer-drug delivery carriers for the theranostics of tumor in an intelligent and on-demand manner. STATEMENT OF SIGNIFICANCE: MRI is one of the most frequently used imaging techniques in daily clinics for cancer diagnosis. Using contrast agents (CAs) in MRI can afford much clearer and enlarged images of detectable organs. Gadolinium (Gd(3+))-based T1-positive CAs are widely used but associated with the risk of nephrogenic systemic fibrosis. To achieve much safer CAs, various Mn(2+)-based T1-positive CAs have been reported, such as MnO or core-shell MnOx-based nanoparticles. However, the efficiency of these CAs is still lower. Herein, we report a novel kind of mesoporous manganese silicate coated silica nanoparticle as CA and anti-cancer drug carrier. Results obtained from this study, especially the pH/redox-responsive T1-MRI feature are helpful for us to further design efficient MnSiO3-based materials for clinical MRI applications.
未加标签：通过一种改进的“SiO2 牺牲和原位硅酸盐生长”方法，在相对较低的水热温度和无碱条件下，构建了一种新型的单分散介孔硅酸锰包覆二氧化硅纳米粒子（MMSSN），作为高效的 T1 加权磁共振成像对比剂（CA）和用于癌症诊断和化疗的药物载体。介孔硅酸锰壳提供了大的比表面积和丰富的暴露的 Mn 顺磁中心与水分子相互作用，使 MMSSNs 具有极高的纵向弛豫率。同时，基于体外和体内的轻度酸性环境或还原剂（GSH）刺激的弛豫率（r1）的显著增强，MMSSNs 表现出高效的 pH/还原响应的 T1-MRI 特征。此外，介孔结构和带负电荷的孔表面使 MMSSNs 能够实现抗癌药物（DOX）的存储和 pH 响应性释放，这适合按需释放以用于肿瘤的化疗。因此，介孔硅酸锰基纳米材料是一种有前途的候选物，可作为 T1-MRI CA 和用于智能和按需肿瘤治疗的抗癌药物输送载体。
意义陈述：磁共振成像（MRI）是癌症诊断中日常临床中最常用的成像技术之一。在 MRI 中使用对比剂（CA）可以提供更清晰和放大的可检测器官图像。基于钆（Gd（3+））的 T1 阳性 CA 被广泛使用，但与肾源性全身纤维化的风险相关。为了实现更安全的 CA，已经报道了各种基于 Mn（2+）的 T1 阳性 CA，例如 MnO 或核壳 MnOx 基纳米粒子。然而，这些 CA 的效率仍然较低。在此，我们报告了一种新型的介孔硅酸锰包覆二氧化硅纳米粒子作为 CA 和抗癌药物载体。本研究获得的结果，特别是 pH/还原响应的 T1-MRI 特征，有助于我们进一步设计用于临床 MRI 应用的高效 MnSiO3 基材料。
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