中国一株新型猪圆环病毒2型（PCV2）的遗传与系统发育分析
Genetic and phylogenetic analysis of a new porcine circovirus type 2 (PCV2) strain in China.
作者信息
Zhang Dan, He Kongwang, Wen Libin, Fan Hongjie
机构信息
Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, National Center for Engineering Research of Veterinary Bio-products, Nanjing, 210000, China.
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
出版信息
Arch Virol. 2015 Dec;160(12):3149-51. doi: 10.1007/s00705-015-2615-8. Epub 2015 Sep 23.
Porcine circovirus type 2 (PCV2) is the etiological agent associated with several pig diseases that are collectively referred to as porcine circovirus-associated disease (PCVAD). Unfortunately, PCV2 has had a serious economic impact on the swine industry. In this study, we report the genome sequence of a novel PCV2 isolate (JS2015) identified in pigs in Jiang Su, China. The complete DNA sequence was 1766 nucleotides long with an A+T content of 52.7%. It lacked a guanine (G) at nucleotide position 1045 compared to other reference PCV2 strains with a sequence length of 1766 nucleotides. Genetic characterization and phylogenetic analysis showed that the isolate JS2015 was most closely related to members of the PCV2d (AY181946) lineage. Our data provide insight into the epidemiology of porcine circovirus and may facilitate further study of the origin and evolution of PCV2.
猪圆环病毒2型（PCV2）是与几种猪病相关的病原体，这些疾病统称为猪圆环病毒相关疾病（PCVAD）。不幸的是，PCV2对养猪业造成了严重的经济影响。在本研究中，我们报告了在中国江苏猪中鉴定出的一种新型PCV2分离株（JS2015）的基因组序列。完整的DNA序列长1766个核苷酸，A+T含量为52.7%。与其他序列长度为1766个核苷酸的参考PCV2毒株相比，它在核苷酸位置1045处缺少一个鸟嘌呤（G）。遗传特征和系统发育分析表明，分离株JS2015与PCV2d（AY181946）谱系的成员关系最为密切。我们的数据为猪圆环病毒的流行病学提供了见解，并可能有助于进一步研究PCV2的起源和进化。
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