Potentiation of cyclophosphamide-induced enhancement of experimental metastasis by splenectomy.
作者信息
Strzadała L, Rak J, Zioło E, Kuśnierczyk H, Radzikowski C
机构信息
Laboratory of Tumor Immunology, Institute of Immunology and Experimental Therapy, Wroclaw.
出版信息
Arch Immunol Ther Exp (Warsz). 1989;37(3-4):399-403.
PMID:2639636
Abstract
Role of spleen in CY-induced enhancement of experimental lung metastases of Lewis Lung Carcinoma LL2 cells was studied. Reconstitution with spleen cells abolished the enhancing effect of CY. Conversely, removal of spleen in CY treated mice caused about two-fold increase in the number of metastases. In addition in splenectomized mice, the effect of CY was augmented.
摘要
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