靶向Wnt/β-连环蛋白信号通路的抗癌药物研发
Development of anticancer agents targeting the Wnt/β-catenin signaling.
作者信息
Zhang Xiangqian, Hao Jijun
机构信息
College of Life Science, Yan'an University Yan'an 716000, Shaanxi, China.
College of Veterinary Medicine, Western University of Health Sciences Pomona, CA 91766, USA ; Graduate College of Biomedical Sciences, Western University of Health Sciences Pomona, CA, 91766, USA.
出版信息
Am J Cancer Res. 2015 Jul 15;5(8):2344-60. eCollection 2015.
Abstract
Wnt/β-catenin signaling plays indispensable roles in both embryonic development and adult homeostasis. Abnormal regulation of this pathway is implicated in many types of cancer. Consequently, substantial efforts have made to develop therapeutic agents as anticancer drugs by specifically targeting the Wnt/β-catenin pathway. Here we systematically review the potential therapeutic agents that have been developed to date for inhibition of the Wnt/β-catenin cascade as well as current status of clinical trials of some of these agents.
摘要
Wnt/β-连环蛋白信号通路在胚胎发育和成人内环境稳态中均发挥着不可或缺的作用。该信号通路的异常调控与多种癌症相关。因此，人们已付出巨大努力，通过特异性靶向Wnt/β-连环蛋白信号通路来开发作为抗癌药物的治疗剂。在此，我们系统地综述了迄今为止已开发出的用于抑制Wnt/β-连环蛋白级联反应的潜在治疗剂，以及其中一些药物的临床试验现状。
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