Division of Experimental Pathology, Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA.
Annu Rev Pathol. 2018 Jan 24;13:351-378. doi: 10.1146/annurev-pathol-020117-044010. Epub 2017 Nov 10.
The liver is an organ that performs a multitude of functions, and its health is pertinent and indispensable to survival. Thus, the cellular and molecular machinery driving hepatic functions is of utmost relevance. The Wnt signaling pathway is one such signaling cascade that enables hepatic homeostasis and contributes to unique hepatic attributes such as metabolic zonation and regeneration. The Wnt/β-catenin pathway plays a role in almost every facet of liver biology. Furthermore, its aberrant activation is also a hallmark of various hepatic pathologies. In addition to its signaling function, β-catenin also plays a role at adherens junctions. Wnt/β-catenin signaling also influences the function of many different cell types. Due to this myriad of functions, Wnt/β-catenin signaling is complex, context-dependent, and highly regulated. In this review, we discuss the Wnt/β-catenin signaling pathway, its role in cell-cell adhesion and liver function, and the cell type-specific roles of Wnt/β-catenin signaling as it relates to liver physiology and pathobiology.
肝脏是一个执行多种功能的器官，其健康对生存至关重要。因此，驱动肝脏功能的细胞和分子机制至关重要。Wnt 信号通路就是这样一种信号级联，它使肝脏维持内稳态，并有助于肝脏的独特属性，如代谢分区和再生。Wnt/β-catenin 途径在肝脏生物学的几乎各个方面都发挥作用。此外，其异常激活也是各种肝脏病理的标志。除了信号功能外，β-catenin 还在黏着连接中发挥作用。Wnt/β-catenin 信号还影响许多不同细胞类型的功能。由于具有这种多样的功能，Wnt/β-catenin 信号复杂、依赖于上下文且受到高度调节。在这篇综述中，我们讨论了 Wnt/β-catenin 信号通路、它在细胞-细胞黏附中的作用以及与肝脏生理学和病理生理学相关的 Wnt/β-catenin 信号在特定细胞类型中的作用。
