Kuppuswamy Annapoorna, Rothwell John, Ward Nick
aSobell Department of Motor Neuroscience, UCL Institute of Neurology bThe National Hospital for Neurology and Neurosurgery cUCLPartners Centre for Neurorehabilitation, London, UK.
Curr Opin Neurol. 2015 Dec;28(6):582-6. doi: 10.1097/WCO.0000000000000260.
This review examines recent studies in poststroke fatigue that might contribute in understanding the pathophysiology of poststroke fatigue. Poststroke fatigue is a common problem in stroke survivors. Little is known about the pathophysiology of chronic fatigue in stroke survivors. It has long been thought of as a neuropsychiatric problem. However, there is gathering evidence to the contrary. In this study, we propose a new model of poststroke fatigue based on recent findings of corticomotor neurophysiological, behavioural, and perceptual deficits in the poststroke fatigue population.
The current evidence suggests that poststroke fatigue may not be a neuropsychiatric problem but a problem of the sensorimotor system. Future studies need to address the causal link between sensorimotor deficits and poststroke fatigue.
本综述探讨了近期关于中风后疲劳的研究，这些研究可能有助于理解中风后疲劳的病理生理学。中风后疲劳是中风幸存者中常见的问题。对于中风幸存者慢性疲劳的病理生理学知之甚少。长期以来，它一直被认为是一个神经精神问题。然而，越来越多的证据表明情况并非如此。在本研究中，我们基于近期对中风后疲劳人群的皮质运动神经生理学、行为和感知缺陷的研究结果，提出了一种新的中风后疲劳模型。
目前的证据表明，中风后疲劳可能不是神经精神问题，而是感觉运动系统的问题。未来的研究需要解决感觉运动缺陷与中风后疲劳之间的因果关系。
