Costa D C, Santi G L de, Crescêncio J C, Seabra L P, Carvalho E E V, Papa V, Marques F, Gallo Junior L, Schmidt A
Laboratório de Fisiologia do Exercício, Divisão de Cardiologia, Departamento de Clínica Médica, Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Braz J Med Biol Res. 2015 Dec;48(12):1136-44. doi: 10.1590/1414-431X20154692. Epub 2015 Sep 18.
This study aimed to analyze the agreement between measurements of unloaded oxygen uptake and peak oxygen uptake based on equations proposed by Wasserman and on real measurements directly obtained with the ergospirometry system. We performed an incremental cardiopulmonary exercise test (CPET), which was applied to two groups of sedentary male subjects: one apparently healthy group (HG, n=12) and the other had stable coronary artery disease (n=16). The mean age in the HG was 47±4 years and that in the coronary artery disease group (CG) was 57±8 years. Both groups performed CPET on a cycle ergometer with a ramp-type protocol at an intensity that was calculated according to the Wasserman equation. In the HG, there was no significant difference between measurements predicted by the formula and real measurements obtained in CPET in the unloaded condition. However, at peak effort, a significant difference was observed between oxygen uptake (V˙O2)peak(predicted)and V˙O2peak(real)(nonparametric Wilcoxon test). In the CG, there was a significant difference of 116.26 mL/min between the predicted values by the formula and the real values obtained in the unloaded condition. A significant difference in peak effort was found, where V˙O2peak(real)was 40% lower than V˙O2peak(predicted)(nonparametric Wilcoxon test). There was no agreement between the real and predicted measurements as analyzed by Lin's coefficient or the Bland and Altman model. The Wasserman formula does not appear to be appropriate for prediction of functional capacity of volunteers. Therefore, this formula cannot precisely predict the increase in power in incremental CPET on a cycle ergometer.
本研究旨在根据瓦瑟曼提出的公式以及通过肺功能仪系统直接获得的实际测量值，分析静息摄氧量和峰值摄氧量测量值之间的一致性。我们对两组久坐不动的男性受试者进行了递增式心肺运动试验（CPET）：一组为明显健康组（HG，n = 12），另一组患有稳定型冠状动脉疾病（n = 16）。HG组的平均年龄为47±4岁，冠状动脉疾病组（CG）的平均年龄为57±8岁。两组均在自行车测力计上按照斜坡式方案进行CPET，强度根据瓦瑟曼公式计算。在HG组中，公式预测值与CPET在静息状态下获得的实际测量值之间无显著差异。然而，在峰值用力时，摄氧量（V˙O2）峰值（预测值）与V˙O2峰值（实际值）之间观察到显著差异（非参数威尔科克森检验）。在CG组中，公式预测值与静息状态下获得的实际值之间存在116.26 mL/min的显著差异。在峰值用力时发现了显著差异，其中V˙O2峰值（实际值）比V˙O2峰值（预测值）低40%（非参数威尔科克森检验）。根据林氏系数或布兰德-奥特曼模型分析，实际测量值与预测值之间不一致。瓦瑟曼公式似乎不适用于预测志愿者的功能能力。因此该公式无法精确预测自行车测力计递增式CPET中功率的增加。
