被搁置的 4-1BB 抗体卷土重来。

Shelved 4-1BB Antibodies Make Comeback.

出版信息

Cancer Discov. 2015 Nov;5(11):1118. doi: 10.1158/2159-8290.CD-ND2015-003. Epub 2015 Sep 23.

DOI:10.1158/2159-8290.CD-ND2015-003

Abstract

New trials are reexamining 4-1BB antibodies for a variety of cancers. Development of the drugs had stalled due to concerns about toxicity, but recent studies in animals, as well as early-phase trials, suggest that new formulations of the drugs may be less toxic-and potentially more potent-when combined with other therapies.

摘要

新的试验正在重新评估 4-1BB 抗体在各种癌症中的应用。由于对毒性的担忧，这些药物的开发一度停滞，但最近在动物身上进行的研究以及早期临床试验表明，当与其他疗法联合使用时，这些药物的新配方可能毒性更小——而且潜在效力更强。