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伴有卫星灶的肢端黑色素瘤,伪装成长期糖尿病溃疡:极具迷惑性。

Acral melanoma with satellitosis, disguised as a longstanding diabetic ulcer: a great mimicry.

作者信息

Mansur A Tulin, Demirci Gulsen T, Ozel Omer, Ozker Emre, Yıldız Semsi

机构信息

Department of Dermatology, Baskent İstanbul University Hospital, İstanbul, Turkey.

Department of Orthopedic Surgery, Baskent İstanbul University Hospital, İstanbul, Turkey.

出版信息

Int Wound J. 2016 Oct;13(5):1006-8. doi: 10.1111/iwj.12481. Epub 2015 Sep 24.

Abstract

Acral lentiginous melanoma affects the palms, soles, and nail apparatus. Around 3-15% of all cutaneous melanomas are located on the foot and have a poorer prognosis than melanoma elsewhere. Possible reasons for this prognostic difference may be omitting this area during routine skin check by both the patient and the physicians, in addition to misdiagnosis of melanoma as other benign skin lesions. We describe here an elderly female patient treated for a non-healing foot ulcer interpreted as a diabetic ulcer, which after 2 years was diagnosed as acral melanoma with satellitosis. Histopathological examination of the amputated distal phalanx revealed an advanced stage melanoma with 1·2 cm Breslow thickness and of Clark level 5. Dermoscopy of the bluish papulonodules scattered on the dorsal foot showed characteristic findings described for metastasis of skin melanoma. This case underlines the importance of considering skin malignancies in case of chronic, non-healing ulcers in diabetic patients. Furthermore, we point out the critical significance of skin examination as a whole, and dermoscopy being an important tool in the diagnosis of melanoma and/or cutaneous melanoma metastasis.

摘要

肢端雀斑样痣性黑色素瘤累及手掌、足底和甲器。所有皮肤黑色素瘤中约3% - 15%位于足部,其预后比其他部位的黑色素瘤更差。这种预后差异的可能原因包括患者和医生在常规皮肤检查时遗漏该区域,以及将黑色素瘤误诊为其他良性皮肤病变。我们在此描述一名老年女性患者,最初因足部溃疡不愈合被诊断为糖尿病溃疡进行治疗,2年后被诊断为伴有卫星灶的肢端黑色素瘤。对截肢的远端趾骨进行组织病理学检查发现为晚期黑色素瘤,Breslow厚度为1.2 cm,Clark分级为5级。对足背散在的蓝色丘疹结节进行皮肤镜检查显示出皮肤黑色素瘤转移所描述的特征性表现。该病例强调了糖尿病患者出现慢性、不愈合溃疡时考虑皮肤恶性肿瘤的重要性。此外,我们指出全面皮肤检查的关键意义,以及皮肤镜检查作为诊断黑色素瘤和/或皮肤黑色素瘤转移的重要工具的意义。

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