Thomas Susan, Meng Yuan-Xiang, Patel Vijaykumar G, Strayhorn Gregory
Department of Family Medicine, Morehouse School of Medicine, 1513 East Cleveland Avenue, Building 100, Suite 300A, Atlanta, GA 30344, USA.
Case Rep Endocrinol. 2012;2012:502806. doi: 10.1155/2012/502806. Epub 2012 Apr 4.
Background. Acral lentiginous melanoma (ALM) is a less-common form of melanoma in US, and it accounts for about 5% of all diagnosed melanomas in US. ALM is often overlooked until it is well advanced because of the lesion's location and its atypical appearance in the early stages. We present a case of ALM initially presented as a diabetic foot ulcer. Case Report. An 81-year-old man initially presented to the primary care clinic with a right foot diabetic ulcer. There was a large plantar, dark-colored ulcer that bled easy. Initial excision biopsy revealed Clark's Level IV ALM. Subsequent definitive wide excision and sentinel node biopsy confirmed ALM with metastasis to inguinal lymph nodes (stage IIIb). The treatment included wide margin excision of the lesion with en bloc amputations of 4th and 5th toes, followed by adjuvant chemotherapy. Discussion. The development of ALM may potentially relate to diabetes as a reported higher prevalence of diabetes with ALM patients. Conclusion. The difficulty in early diagnosing of ALM remains as a formidable challenge particularly in diabetic patients who commonly develop plantar foot ulcers due to the diabetic neuropathy. This case reiterates the importance of a thorough foot exam in such patients.
背景。肢端雀斑样痣黑素瘤(ALM)在美国是一种较罕见的黑素瘤形式,约占美国所有确诊黑素瘤的5%。由于该病变的位置及其早期的非典型外观,ALM常常在病情进展到较严重时才被发现。我们报告一例最初表现为糖尿病足溃疡的ALM病例。病例报告。一名81岁男性最初因右脚糖尿病溃疡就诊于初级保健诊所。足底有一个大的深色溃疡,容易出血。初始切除活检显示为克拉克IV级ALM。随后的根治性广泛切除和前哨淋巴结活检证实为ALM伴腹股沟淋巴结转移(IIIb期)。治疗包括对病变进行宽切缘切除并整块切除第4和第5趾,随后进行辅助化疗。讨论。ALM的发生可能与糖尿病有关,因为据报道ALM患者中糖尿病的患病率较高。结论。ALM的早期诊断困难仍然是一个巨大挑战,尤其是在因糖尿病神经病变而常发生足底溃疡的糖尿病患者中。本病例重申了对此类患者进行全面足部检查的重要性。