McKerrell Thomas, Vassiliou George S
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. Department of Haematology, Cambridge University Hospitals NHS Trust, Cambridge CB2 0QQ, UK. Department of Haematology, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XY, UK.
Sci Transl Med. 2015 Sep 23;7(306):306fs38. doi: 10.1126/scitranslmed.aac4428.
The presence of subclinical hemopoietic clones driven by leukemia-associated mutations is commonly observed in old age, but also occurs in younger people. We recently found that some leukemia-initiating mutations appear able to found hemopoietic clones in advanced old age. We discuss the biological and clinical implications of these findings.
由白血病相关突变驱动的亚临床造血克隆在老年人中普遍存在,但在年轻人中也会出现。我们最近发现,一些白血病起始突变似乎能够在高龄时形成造血克隆。我们讨论了这些发现的生物学和临床意义。