转化与征服：慢性髓性白血病细胞的策略。

Convert and conquer: the strategy of chronic myelogenous leukemic cells.

机构信息

Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain; Stem Cell Institute and Department of Haematology, University of Cambridge and National Health Service Blood and Transplant, Cambridge Biomedical Campus, CB2 0PT Cambridge, UK.

Stem Cell Niche Pathophysiology Group, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 Madrid, Spain.

出版信息

Cancer Cell. 2015 May 11;27(5):611-3. doi: 10.1016/j.ccell.2015.04.012.

DOI:10.1016/j.ccell.2015.04.012

PMID:25965567

Abstract

Emerging evidence is contributing to explain how leukemias disrupt normal blood cell production. In this issue of Cancer Cell, Welner and colleagues show that, during the development of chronic myeloid leukemia, mutated cells transform normal hematopoietic progenitors into "leukemic like" cells through IL-6 secretion, proposing a new cellular target.

摘要

新出现的证据有助于解释白血病如何扰乱正常血细胞的产生。在本期《癌细胞》杂志中，Welner 及其同事表明，在慢性髓性白血病的发展过程中，突变细胞通过分泌白细胞介素 6 将正常造血祖细胞转化为“类白血病”细胞，提出了一个新的细胞靶标。