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De novo autoimmune hepatitis following liver transplantation for primary biliary cirrhosis: an unusual cause of late grafts dysfunction.原发性胆汁性肝硬化肝移植后新发自身免疫性肝炎：晚期移植物功能障碍的罕见原因。
Pan Afr Med J. 2015 May 4;21:2. doi: 10.11604/pamj.2015.21.2.6789. eCollection 2015.
2
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Clinical and biochemical features and therapy responses in primary biliary cirrhosis and primary biliary cirrhosis-autoimmune hepatitis overlap syndrome.原发性胆汁性肝硬化及原发性胆汁性肝硬化-自身免疫性肝炎重叠综合征的临床、生化特征及治疗反应
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A 38-year-old African-American woman with an unusually rapid progression of "Primary Biliary Cirrhosis": a missed opportunity!一名38岁非裔美国女性，患有进展异常迅速的“原发性胆汁性肝硬化”：一个被错失的诊断机会！
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本文引用的文献

1
Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation.肝移植后自身免疫性肝炎的诊断、发病机制和治疗。
Dig Dis Sci. 2012 Sep;57(9):2248-66. doi: 10.1007/s10620-012-2179-3. Epub 2012 May 6.
2
Autoimmune hepatitis after liver transplantation.肝移植后自身免疫性肝炎。
Clin Gastroenterol Hepatol. 2012 Apr;10(4):346-53. doi: 10.1016/j.cgh.2011.10.028. Epub 2011 Nov 2.
3
De novo autoimmune hepatitis in Korean children after liver transplantation: a single institution's experience.韩国儿童肝移植后新发自身免疫性肝炎：单中心经验
Transplant Proc. 2011 Jul-Aug;43(6):2394-6. doi: 10.1016/j.transproceed.2011.05.030.
4
De novo autoimmune hepatitis with centrilobular necrosis following liver transplantation for primary biliary cirrhosis: a case report.原发性胆汁性肝硬化肝移植后发生的伴有小叶中心坏死的新发自身免疫性肝炎：一例报告
Transplant Proc. 2010 Nov;42(9):3854-7. doi: 10.1016/j.transproceed.2010.08.062.
5
Risk factors for developing de novo autoimmune hepatitis associated with anti-glutathione S-transferase T1 antibodies after liver transplantation.肝移植后与抗谷胱甘肽S-转移酶T1抗体相关的新发自身免疫性肝炎的危险因素。
Liver Transpl. 2009 May;15(5):530-9. doi: 10.1002/lt.21721.
6
Chronic liver allograft dysfunction.慢性肝移植功能障碍
Transplant Proc. 2009 Mar;41(2):773-6. doi: 10.1016/j.transproceed.2009.01.038.
7
Clinical relevance of autoantibodies after pediatric liver transplantation.小儿肝移植后自身抗体的临床相关性
Clin Transplant. 2007 May-Jun;21(3):427-32. doi: 10.1111/j.1399-0012.2007.00667.x.
8
Liver biopsy interpretation for causes of late liver allograft dysfunction.肝活检对晚期肝移植功能障碍病因的解读。
Hepatology. 2006 Aug;44(2):489-501. doi: 10.1002/hep.21280.
9
Cyclosporin A-induced autoimmunity: the result of defective de novo T-cell development.
Folia Biol (Praha). 1998;44(1):1-9.
10
De-novo autoimmune hepatitis after liver transplantation.肝移植后新发自身免疫性肝炎
Lancet. 1998 Feb 7;351(9100):409-13. doi: 10.1016/S0140-6736(97)06478-7.

原发性胆汁性肝硬化肝移植后新发自身免疫性肝炎：晚期移植物功能障碍的罕见原因。

De novo autoimmune hepatitis following liver transplantation for primary biliary cirrhosis: an unusual cause of late grafts dysfunction.

作者信息

Ennaifer Rym, Ayadi Hend, Romdhane Haifa, Cheikh Meriem, Mestiri Hafedh, Khalfallah Taher, Hadj Najet Bel

机构信息

Department of Hepato-Gastro-Enterology, Mongi Slim Hospital, Tunis, Tunisia ; University of Tunis El Manar, Faculty of Medicine, Tunis, Tunisia.

University of Tunis El Manar, Faculty of Medicine, Tunis, Tunisia ; Departement of Surgery, Mongi Slim Hospital, Tunis, Tunisia.

出版信息

Pan Afr Med J. 2015 May 4;21:2. doi: 10.11604/pamj.2015.21.2.6789. eCollection 2015.

DOI:10.11604/pamj.2015.21.2.6789
PMID:26401196
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4561156/
Abstract

De novo autoimmune hepatitis (AIH) is a rare disorder first described in 1998. It occurs in patients who underwent liver transplantation for a different etiology. We present the case of a 56-year-old woman who was diagnosed with primary biliary cirrhosis and had liver transplantation for refractory pruritis. Seven years after transplantation, she presented alterations in the hepatic profile with hypertransaminasemia, elevated alkaline phosphatase and gamma-glutamyl-transferase. Her liver functions test also showed elevated IgG levels. Serum autoantibodies were negative except for antimitochondrial antibodies. Histological findings indicated features of AIH without bile duct damage or loss. She had a pretreatment AIH score of 13 points and a post treatment score of 15 points according to the International AIH Group. The patient was treated effectively with prednisolone and her liver function and globulin levels rapidly returned to normal.

摘要

新发自身免疫性肝炎（AIH）是一种罕见疾病，于1998年首次被描述。它发生在因其他病因接受肝移植的患者中。我们报告一例56岁女性病例，该患者被诊断为原发性胆汁性肝硬化，并因难治性瘙痒症接受了肝移植。移植后七年，她出现肝功能异常，伴有转氨酶升高、碱性磷酸酶和γ-谷氨酰转移酶升高。她的肝功能检查还显示IgG水平升高。除抗线粒体抗体外，血清自身抗体均为阴性。组织学检查结果显示为AIH特征，无胆管损伤或缺失。根据国际AIH小组标准，她治疗前的AIH评分为13分，治疗后的评分为15分。该患者接受泼尼松龙治疗有效，其肝功能和球蛋白水平迅速恢复正常。