104 Psychology Building, University of Missouri - Columbia, Columbia, MO 65211 USA.
210 McAlester Hall, University of Missouri - Columbia, Columbia, MO 65211 USA.
Borderline Personal Disord Emot Dysregul. 2015 Jul 24;2:11. doi: 10.1186/s40479-015-0032-y. eCollection 2015.
The comorbidity of borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) is frequent, yet not well understood. The influence of childhood sexual abuse (CSA) in the development of this comorbidity has been a focus of prior clinical studies, but empirical evidence to generalize this focus to the broader population is lacking. Primary aims of the present study included evaluation of: (a) the association of this comorbidity with decrements in health-related quality of life (HRQOL) and (b) the importance of CSA as a predictive factor for this comorbidity in a general population sample.
We utilized data from Wave 2 of the National Epidemiological Survey on Alcohol and Related Conditions, a nationally representative face-to-face survey evaluating mental health in the non-institutionalized adult population of the United States. Data from respondents who met criteria for BPD and/or PTSD were analyzed (N = 4104) to assess potential associations between and among lifetime BPD-PTSD comorbidity, CSA, gender, healthcare usage, and mental and physical HRQOL.
Lifetime comorbidity of BPD and PTSD was associated with more dysfunction than either individual disorder; and the factors of gender, age, and CSA exhibited significant effects in the prediction of this comorbidity and associated decrements in HRQOL.
Results support the measured focus on CSA as an important, but not necessary, etiologic factor and emphasize this comorbidity as a source of greater suffering and public health burden than either BPD or PTSD alone. The differential impact of these disorders occurring alone versus in comorbid form highlights the importance of diagnosing both BPD and PTSD and attending to lifetime comorbidity.
边缘型人格障碍(BPD)和创伤后应激障碍(PTSD)共病较为常见,但目前尚未完全阐明其发病机制。既往临床研究关注童年期性虐待(CSA)对共病发展的影响,但将这一关注推广到更广泛人群的实证证据尚缺乏。本研究的主要目的包括评估:(a)这种共病与健康相关生活质量(HRQOL)下降的相关性;(b)在一般人群样本中,CSA 作为共病预测因素的重要性。
我们利用美国全国酒精相关状况流行病学调查第 2 波的数据,该调查是一项全国代表性的面对面调查,评估非住院成年人群的心理健康。对符合 BPD 和/或 PTSD 标准的受访者的数据(N=4104)进行分析,以评估一生中 BPD-PTSD 共病、CSA、性别、医疗保健使用情况以及心理和生理 HRQOL 之间的潜在关联。
BPD 和 PTSD 的终生共病与更多功能障碍相关,比任何一种单独的疾病都更严重;性别、年龄和 CSA 等因素对共病及其相关 HRQOL 下降的预测具有显著影响。
结果支持将 CSA 作为一个重要但非必要的病因学因素的有针对性关注,并强调这种共病比 BPD 或 PTSD 单独存在时更能带来痛苦和公共卫生负担。这些疾病单独存在和共病形式对生活质量的不同影响,凸显了同时诊断 BPD 和 PTSD 以及关注终生共病的重要性。