Sahib Ahmed Salih, Mohammed Imad Hashim, Sloo Saja Akram
Department of Pharmacology, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.
J Intercult Ethnopharmacol. 2014 Jul-Sep;3(3):109-12. doi: 10.5455/jice.20140523104104. Epub 2014 May 25.
Giardia lamblia is the most common intestinal parasite of humans identified worldwide. In spite of metronidazole (Met) is the most commonly used drug for the treatment of giardiasis in humans, low patient compliance and side-effects, especially in children encourage efforts to look for new and safe agent; many plants used in folk medicine thought to have antigiardial effect, Anethum graveolens (AG) (dill) is an annual herb cultivated in Iraq used both as a medicinal agent and as food spice. The aim of this study was to investigate the effect of aqueous extract (AE) of AG leave in the treatment of giardiasis, compared with that of standard drug Met.
A prospective randomized clinical trial was carried out on 28 pediatric patients of both sexes with age of <1 year ranging from 3 to 11 months, who attend to outpatient private clinic in Baghdad for a period of 6 months from June 2013 to December 2013,Patients participate in this study were allocated into two groups Group A composed of 14 patients treated with Met 15 mg/kg 3 times a day for 5 days. Group B composed of 14 patients treated with AGAE 1 ml 3 times a day for 5 days. Stool samples were collected at 0 time before administration of treatment, after 5 days and after 14 days from starting the treatments to check the efficacy of treatment.
Administration of AGAE results in a significant decrease in incidence of G. lamblia after 5 days of treatment indicating the efficacy of AGAE in the treatment of giardiasis a result that is comparable to that of Met.
This study showed that pediatric patients with giardiasis may benefit from 5 days treatment with AGAE administered as 1 ml 3 times daily, the improvement in the symptom with this herbal agent was comparable to the standard pharmacological agent Met; results showed that AG is safe and tolerable over treatment course.
蓝氏贾第鞭毛虫是全球范围内确认的人类最常见的肠道寄生虫。尽管甲硝唑（Met）是治疗人类贾第虫病最常用的药物，但患者依从性低以及副作用，尤其是在儿童中，促使人们努力寻找新的安全药物；许多用于民间医学的植物被认为具有抗贾第虫作用，莳萝（AG）（Anethum graveolens）是伊拉克种植的一年生草本植物，既用作药物又用作食品香料。本研究的目的是研究AG叶水提取物（AE）治疗贾第虫病的效果，并与标准药物Met进行比较。
对28名年龄在3至11个月、年龄小于1岁的儿科患者进行了一项前瞻性随机临床试验，这些患者于2013年6月至2013年12月期间在巴格达的一家私人门诊就诊了6个月。参与本研究的患者被分为两组，A组由14名患者组成，用Met 15 mg/kg，每日3次，共治疗5天。B组由14名患者组成，用AGAE 1 ml，每日3次，共治疗5天。在治疗前第0天、治疗5天后和开始治疗14天后收集粪便样本，以检查治疗效果。
治疗5天后，AGAE的给药导致蓝氏贾第鞭毛虫发病率显著降低，表明AGAE在治疗贾第虫病方面有效，这一结果与Met相当。
本研究表明，贾第虫病儿科患者可能从每日3次、每次1 ml的AGAE 5天治疗中获益，这种草药制剂的症状改善与标准药理药物Met相当；结果表明，AG在整个治疗过程中是安全且可耐受的。
